Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women
Reactogenicity and immunogenicity of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant and nonpregnant women
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DOI：
10.1016/j.vaccine.2018.07.012
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发表时间：
2018-10-08
期刊：
影响因子：
5.5
通讯作者：
Edwards, Kathryn M.
中科院分区：
文献类型：
--
作者：
Fortner, Kimberly B.;Swamy, Geeta K.;Edwards, Kathryn M.
目的：破伤风类毒素，减少白喉类毒素，和无细胞百日咳（Tdap）疫苗建议在每次怀孕期间，无论先前的接收。关于反应原性和免疫原性的数据，特别是重复Tdap后的数据有限。我们比较了局部注射部位和全身反应和血清学反应后Tdap在（1）孕妇和非孕妇和（2）孕妇自我报告的前Tdap receiption.Study设计：孕妇（胎龄20-34周）和非孕妇接受Tdap入组这项观察性研究。接种后一周评估注射部位和全身反应。在基线和接种后28天，通过标准化酶联免疫吸附试验测定百日咳毒素、丝状血凝素、百日咳毒素、菌毛、破伤风和白喉特异性IgG抗体滴度。反应原性和血清学反应进行了比较，怀孕状态，并在孕妇自我报告之前Tdap receive.Results：374怀孕和225非孕妇接种。严重的局部或全身反应或“任何”发热并不常见（
Objective: Tetanus toxoid, reduced diphtheria toxoid, and acellular pertusiss (Tdap) vaccine is recommended during each pregnancy, regardless of prior receipt. Data on reactogenicity and immunogenicity, particularly after repeated Tdap, are limited. We compared local injection-site and systemic reactions and serologic response following Tdap in (1) pregnant and nonpregnant women and (2) pregnant women by self-reported prior Tdap receipt.Study design: Pregnant women (gestational age 20-34 weeks) and nonpregnant women receiving Tdap were enrolled in this observational study. Injection-site and systemic reactions were assessed for one week post-vaccination. Pertussis toxin, filamentous hemagglutinin, pertactin, fimbriae, tetanus and diphtheria specific IgG antibody titers were determined by standardized enzyme-linked immunosorbent assay at baseline and 28 days post-vaccination. Reactogenicity and serologic responses were compared by pregnancy status, and within pregnant women by self-reported prior Tdap receipt.Results: 374 pregnant and 225 nonpregnant women were vaccinated. Severe local or systemic reactions or "any" fever were uncommon (