Pathogenesis of NEC: Role of the innate and adaptive immune response.
Pathogenesis of NEC: Role of the innate and adaptive immune response.
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DOI：
10.1053/j.semperi.2016.09.014
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发表时间：
2017-02
影响因子：
3.4
通讯作者：
Denning PW
中科院分区：
文献类型：
--
作者：
Denning TL;Bhatia AM;Kane AF;Patel RM;Denning PW
坏死性小肠结肠炎（NEC）是早产儿的一种毁灭性疾病，病死率高，存活者发病率高。肠道宿主防御系统的不成熟使早产儿肠道易受损伤。一个异常的细菌定植模式，缺乏肠道细菌可能会导致这些主机防御机制的进一步崩溃，诱发婴儿NEC。在这里，我们回顾了先天性和适应性免疫系统在NEC的病理生理学中的作用。
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants with high case fatality and significant morbidity among survivors. Immaturity of intestinal host defenses predisposes the premature infant gut to injury. An abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of these host defense mechanisms, predisposing the infant to NEC. Here, we review the role of the innate and adaptive immune system in the pathophysiology of NEC.