Longitudinal evaluation of patients with cancer in the oral tongue, tonsils, or base of tongue - Does interstitial radiation dose affect quality of life?
Longitudinal evaluation of patients with cancer in the oral tongue, tonsils, or base of tongue - Does interstitial radiation dose affect quality of life?
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DOI：
10.1016/j.brachy.2005.06.001
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发表时间：
2005-01-01
期刊：
影响因子：
1.9
通讯作者：
Hammerlid, Eva
中科院分区：
文献类型：
--
作者：
Petruson, Karin;Mercke, Claes;Hammerlid, Eva
目的：在一项前瞻性纵向研究中评估口腔舌癌、扁桃体癌或舌底癌患者的健康相关生活质量（HRQL），并探讨HRQL评分与间质辐射剂量、剂量率和种植体体积之间的相关性。方法与材料：采用欧洲癌症研究与治疗组织生活质量问卷Core-30和欧洲癌症研究与治疗组织头颈部模块对90例口腔癌（n = 30）和扁桃体或舌底癌（n = 60）患者在诊断时、开始治疗3个月、12个月和36个月后进行评估。结果：所有患者的HRQL在治疗期间均有所下降。大多数HRQL评分在3年后恢复到基线值；然而，在3年的随访中，60%的口腔癌患者和80%的扁桃体和舌底癌患者报告了口干问题，一半的扁桃体和舌底癌患者报告了吞咽固体食物的问题。近距离治疗质量指标与HRQL评分无相关性。结论：在这项为期3年的随访研究中，口腔舌、扁桃体或舌底癌患者报告了口干和吞咽固体食物的显著问题。(C) 2005美国近距离放射治疗学会。版权所有。
PURPOSE: To evaluate health-related quality of life (HRQL) in patients with oral tongue, tonsil, or base of tongue cancer in a prospective longitudinal study and explore correlations between HRQL scores and interstitial radiation dose, dose rate, and volume of implant.METHODS AND MATERIALS: Ninety patients with oral tongue cancer (n = 30) and tonsil or base of tongue cancer (n = 60) were assessed with the European Organization of Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and the European Organization of Research and Treatment of Cancer Head and Neck module at diagnosis, and after 3, 12, and 36 months of starting treatment.RESULTS: The HRQL of all patients decreased during treatment. Most HRQL scores returned to baseline values after 3 years; however, 60% of patients with oral tongue cancer and 80% with tonsil and base of tongue cancer reported problems with dry mouth and half of the patients with tonsil and base of tongue cancer reported problems with swallowing solid food at the 3-year followup. No correlations between brachytherapy quality indices and HRQL scores were found.CONCLUSIONS: Patients with oral tongue, tonsil, or base of tongue cancer reported significant problems with dry mouth and swallowing solid food throughout this 3-year followup study. (C) 2005 American Brachytherapy Society. All rights reserved.