Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasis.
Cleavage of transmembrane junction proteins and their role in regulating epithelial homeostasis.
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DOI：
10.4161/tisb.24783
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发表时间：
2013-04-01
期刊：
影响因子：
3.1
通讯作者：
Nusrat A
中科院分区：
文献类型：
--
作者：
Nava P;Kamekura R;Nusrat A
上皮组织形成将外部环境与内部组织环境分开的选择性屏障。单个上皮细胞密集排列，并通过不同的细胞间连接结合。细胞间连接蛋白不仅控制上皮的屏障特性，而且在调节上皮稳态（包括细胞增殖、迁移、分化和调节脱落）中起重要作用。最近的研究表明，在生理成熟过程中以及在病理状态如炎症和癌症中，几种蛋白酶靶向上皮连接蛋白。本文综述了跨膜连接蛋白切割的机制和生物学后果。连接蛋白裂解产物对炎症和癌症发病机制的影响进行了讨论。
Epithelial tissues form a selective barrier that separates the external environment from the internal tissue milieu. Single epithelial cells are densely packed and associate via distinct intercellular junctions. Intercellular junction proteins not only control barrier properties of the epithelium but also play an important role in regulating epithelial homeostasis that encompasses cell proliferation, migration, differentiation and regulated shedding. Recent studies have revealed that several proteases target epithelial junction proteins during physiological maturation as well as in pathologic states such as inflammation and cancer. This review discusses mechanisms and biological consequences of transmembrane junction protein cleavage. The influence of junction protein cleavage products on pathogenesis of inflammation and cancer is discussed.