An Experimental Study of Bone Healing Around the Titanium Screw Implants in Ovariectomized Rats: Enhancement of Bone Healing by Bone Marrow Stromal Cells Transplantation
An Experimental Study of Bone Healing Around the Titanium Screw Implants in Ovariectomized Rats: Enhancement of Bone Healing by Bone Marrow Stromal Cells Transplantation
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DOI：
10.1097/id.0b013e3182199543
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发表时间：
2011-06
影响因子：
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通讯作者：
Yasuhiro Okamoto;Hideo Tateishi;K. Kinoshita;S. Tsuchiya;H. Hibi;M. Ueda
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文献类型：
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作者：
Yasuhiro Okamoto;Hideo Tateishi;K. Kinoshita;S. Tsuchiya;H. Hibi;M. Ueda
目的：观察骨髓基质干细胞（BMSCs）移植于大鼠股骨后对种植体周围骨质量的影响。材料与方法：将SD大鼠分为3组：去卵巢组（OVX组）、假手术组（SHAM组）和OVX组移植BMSCs组（OVX-BMSCs组）。OVX-BMSCs组，将1 × 105个BMSCs植入股骨内。获得骨与植入物接触的每个值以及每个皮质骨和松质骨的骨面积。测量距种植体500 m宽度的骨密度。结果：OVX组松质骨的骨-种植体接触率、骨面积和骨密度均显著高于OVX组。结论：骨髓间充质干细胞移植治疗可促进种植体周围松质骨局部骨愈合，并显著提高种植体与骨结合力。
Purpose:This study is to evaluate the bone quality of surrounding areas of implants with bone marrow stromal cells (BMSCs) transplantation to rat femur, which have become osteoporosis-induced models. Materials and Methods:The Sprague-Dawley rats were divided into 3 groups: the first group where their ovaries were removed (OVX group), the second group where a sham surgery was given (SHAM group), and the third group where BMSCs were transplanted to an OVX group (OVX-BMSCs group). In the OVX-BMSCs group, 1 × 105 BMSCs were transplanted into femur with implant. Each value of the bone to implant contact and the bone area of each cortical bone and cancellous bone was obtained. Bone density of the width of 500 m from the implants was measured. Results:Each ratio of bone to implant contact, bone area, and bone density in the OVX-BMSCs group was significantly higher than those of OVX group as to the cancellous bone. Conclusion:The BMSCs transplantation therapy improved local bone healing in the cancellous bone surrounding implants and also significantly improved bone binding with implants.