OPeNing the Epithelial Barrier: Osteopontin Preserves Gut Barrier Function During Intestinal Inflammation.
OPeNing the Epithelial Barrier: Osteopontin Preserves Gut Barrier Function During Intestinal Inflammation.
复制标题
打开上皮屏障：骨桥蛋白在肠道炎症期间保留肠道屏障功能。
DOI：
10.1007/s10620-018-5350-7
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nakase H.
中科院分区：
文献类型：
--
作者：
Nakase H.
13、病理事件。相反，iOPN主要存在于细胞质中，缺乏sOPN的N端信号序列[5]。以前的报道主要是通过与αvβ3整合素和分化簇的相互作用来增强TJ相关分子的屏障功能[4]。这些报告没有描述iOPN如何直接促进TJ相关蛋白的功能，尽管Woo等人[6]报道的体外数据证明了iOPN和闭塞表达之间的关联(图1)。在这方面，Woo的数据很耐人寻味，尽管他们的数据的临床意义仍然不确定。总而言之，TJ相关蛋白的失调和内化与肠粘膜通透性增加有关，这导致IBD的发生和发作。目前的研究提供了新的数据支持这一假说，即OPN通过阻止阻滞素的重新分布和磷酸化来促进肠粘膜的完整性。尽管OPN在IBD病理生理学中的作用仍然存在许多问题，但OPN偷偷地支持TJ相关蛋白作为上皮屏障的守护者。
1 3 and pathological events. On the contrary, iOPN is predominantly present in the cytoplasm, lacking the N-terminal signal sequence of sOPN [5]. Previous reports primarily demonstrated the effect of OPN administration on increasing the barrier function of TJ-associated molecules via interaction with αvβ3 integrin and cluster of differentiation (CD44)[4]. These reports did not describe how iOPN may directly contribute to the function of TJ-associated proteins, although in vitro data reported by Woo et al.[6] demonstrated the association between iOPN and occluding expression (Fig. 1). In this regard, Woo’s data are intriguing, although the clinical significance of their data remains uncertain.In summary, dysregulation and internalization of TJ-associated proteins are associated with increased intestinal mucosal permeability, which leads to the onset and flare of IBD. The current study provides new data supporting the hypothesis that OPN contributes to the integrity of intestinal mucosa via the prevention of the redistribution and phosphorylation of occludin. Although many issues remain regarding the contribution of OPN to IBD pathophysiology, OPN furtively supports TJ-associated proteins as guardians of the epithelial barrier.