Cinnamyl Esters Synthesis By Lipase-Catalyzed Transesterification in a Non-Aqueous System
Cinnamyl Esters Synthesis By Lipase-Catalyzed Transesterification in a Non-Aqueous System
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非水体系中脂肪酶催化酯交换合成肉桂酯
DOI：
10.1007/s10562-017-1994-8
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发表时间：
2017-04-01
影响因子：
2.8
通讯作者：
Wei, Dong-zhi
中科院分区：
文献类型：
--
作者：
Cai, Xianghai;Wang, Wei;Wei, Dong-zhi
摘要肉桂醇酯在食品、化妆品和制药工业中作为香料和香料化合物有着广泛的应用。本文主要研究了以肉桂醇和乙酸乙烯为原料合成乙酸肉桂酯的反应条件，包括有机溶剂、反应温度、催化剂用量和摩尔比等反应条件的筛选优化。以正己烷为溶剂，乙酸乙烯酯/肉桂醇2：1，脂肪酶负载L−1 4.0g，反应4h，转化率可达93%。同时考察了脂肪酶LipBA对合成不同碳链长度肉桂酸酯的催化性能。在不同的酰基供体中，丙酸乙烯酯是最好的酰基供体，转化率为96%。与化学催化相比，酶法合成肉桂酸酯是一种有效的方法。
AbstractEsters of cinnamyl alcohol find many applications in food, cosmetic and pharmaceutical industries as flavor and fragrance compounds. The current work focuses on the synthesis of cinnamyl acetate from cinnamyl alcohol and vinyl acetate, including screening optimization of reaction conditions such as organic solvents, temperature, catalyst loading and mole ratio. Conversion (93%) was achieved after 4 h when transesterification was carried out at vinyl acetate/cinnamyl alcohol 2:1, 4.0 g L−1of lipase loading, and at 40 °C in hexane as solvent. Also the catalytic behaviors of lipase LipBA for synthesis different carbon chain lengths of cinnamyl esters were determined. Among the different acyl donors employed, vinyl propionate was found to be the best acyl donor which presents a 96% conversion. Enzymatic synthesis of cinnamyl esters is an efficient process vis-à-vis chemical catalysis.Graphical Abstract