Association of body mass index and waist-to-hip ratio with brain structure UK Biobank study
Association of body mass index and waist-to-hip ratio with brain structure UK Biobank study
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DOI：
10.1212/wnl.0000000000006879
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发表时间：
2019-02-05
期刊：
影响因子：
9.9
通讯作者：
Batty, G. David
中科院分区：
文献类型：
--
作者：
Hamer, Mark;Batty, G. David
目的探讨体重指数（BMI）、腰臀比（WHR）与脑容量的关系。方法我们使用来自英国生物银行研究的横断面数据（n = 9，652，年龄55.4 ± 7.5岁，47.9%为男性）。测量包括BMI、WHR和根据生物阻抗确定的总脂肪量。用结构MRI产生脑图像。结果在对一系列协变量进行调整后，所有肥胖指标的较高水平与较低的灰质体积相关：BMI/1 SD（β系数-4，113，95%置信区间[CI]-4，862至-3，364），WHR（β系数-4，272，95%CI-5，280至-3，264）和脂肪量（β系数-4，590，95%CI-5，386至-3，793）。总体肥胖（BMI >= 30 kg/m2）和中心性肥胖（女性WHR >0.85，男性>0.90）的组合与较瘦成人的最低灰质相关。在Bonferroni校正的无假设检验中，肥胖还与各种区域脑体积相关，包括尾状核、壳核、苍白球和丘脑核。肥胖和白色物质之间没有明显的联系。结论BMI和WHR的联合增高可能是脑灰质萎缩的重要危险因素。
Objective To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume. Methods We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 +/- 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced with structural MRI. Results After adjustment for a range of covariates, higher levels of all obesity measures were related to lower gray matter volume: BMI per 1 SD (beta coefficient -4,113, 95% confidence interval [CI] -4,862 to -3,364), WHR (beta coefficient -4,272, 95% CI -5,280 to -3,264), and fat mass (beta coefficient -4,590, 95% CI -5,386 to -3,793). The combination of overall obesity (BMI >= 30 kg/m(2)) and central obesity (WHR >0.85 for women, >0.90 for men) was associated with the lowest gray matter compared with that in lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes, including caudate, putamen, pallidum, and nucleus accumbens. No associations between obesity and white matter were apparent. Conclusion The combination of heightened BMI and WHR may be an important risk factor for gray matter atrophy.