Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort.
Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort.
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DOI：
10.1289/ehp.1409190
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发表时间：
2016-04
影响因子：
10.4
通讯作者：
Vrijheid M
中科院分区：
文献类型：
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作者：
Casas M;Valvi D;Ballesteros-Gomez A;Gascon M;Fernández MF;Garcia-Esteban R;Iñiguez C;Martínez D;Murcia M;Monfort N;Luque N;Rubio S;Ventura R;Sunyer J;Vrijheid M
产前暴露于双酚A （BPA）和邻苯二甲酸盐可能影响胎儿生长；然而，以前的发现是不一致的，并且基于很少的研究。我们评估了产前暴露于双酚a和邻苯二甲酸盐是否与西班牙488对母婴出生队列中的胎儿生长有关。我们测量了双酚a和八种邻苯二甲酸盐[四种二（2-乙基己基）邻苯二甲酸酯代谢物（DEHPm），邻苯二甲酸一苯酯（MBzP）和三种低分子量邻苯二甲酸酯代谢物（LMWPm）]在妊娠早期和晚期收集的两种尿样中的含量。我们估计了妊娠期间（12-20周和20-34周）股骨长度（FL）、头围（HC）、腹围（AC）、双顶叶直径（BPD）和胎儿体重（EFW）的生长曲线，以及出生体重、出生长度、出生时头围和胎盘重量。总的来说，结果不支持怀孕期间暴露于BPA或DEHPm与胎儿生长参数的关联。产前MBzP暴露与20-34周时的FL呈正相关，MBzP浓度每增加一倍，平均FL增加3.70% （95% CI: 0.75, 6.63%）。MBzP与男孩的出生体重呈正相关（48 g, 95% CI: 6.90），但与女孩无关（-27 g, 95% CI: - 79,25）（相互作用p值= 0.04）。LMWPm邻苯二甲酸单正丁酯（MnBP）与妊娠12-20周时HC呈负相关[占HC平均值的-4.88% (95% CI: -8.36, -1.36%)]。这项研究是首次将重复暴露生物标志物测量和怀孕期间多次生长测量结合起来的研究之一，发现BPA或邻苯二甲酸盐暴露与胎儿生长有关的证据很少。邻苯二甲酸酯代谢物MBzP和MnBP与一些胎儿生长参数有关，但这些发现需要复制。Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. 2016。妊娠期间暴露于双酚A和邻苯二甲酸盐和超声测量胎儿生长在INMA-Sabadell队列。环境卫生展望124:521-528；http://dx.doi.org/10.1289/ehp.1409190
Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent and based on few studies. We assessed whether prenatal exposure to BPA and phthalates was associated with fetal growth in a Spanish birth cohort of 488 mother–child pairs. We measured BPA and eight phthalates [four di(2-ethylhexyl) phthalate metabolites (DEHPm), mono-benzyl phthalate (MBzP), and three low-molecular-weight phthalate metabolites (LMWPm)] in two spot-urine samples collected during the first and third trimester of pregnancy. We estimated growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW) during pregnancy (weeks 12–20 and 20–34), and for birth weight, birth length, head circumference at birth, and placental weight. Overall, results did not support associations of exposure to BPA or DEHPm during pregnancy with fetal growth parameters. Prenatal MBzP exposure was positively associated with FL at 20–34 weeks, resulting in an increase of 3.70% of the average FL (95% CI: 0.75, 6.63%) per doubling of MBzP concentration. MBzP was positively associated with birth weight among boys (48 g; 95% CI: 6, 90) but not in girls (–27 g; 95% CI: –79, 25) (interaction p-value = 0.04). The LMWPm mono-n-butyl phthalate (MnBP) was negatively associated with HC at 12–20 pregnancy weeks [–4.88% of HC average (95% CI: –8.36, –1.36%)]. This study, one of the first to combine repeat exposure biomarker measurements and multiple growth measures during pregnancy, finds little evidence of associations of BPA or phthalate exposures with fetal growth. Phthalate metabolites MBzP and MnBP were associated with some fetal growth parameters, but these findings require replication. Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. 2016. Exposure to bisphenol A and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort. Environ Health Perspect 124:521–528; http://dx.doi.org/10.1289/ehp.1409190