The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients
The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients
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DOI：
10.1007/s10633-008-9150-9
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发表时间：
2009-06-01
影响因子：
1.4
通讯作者：
Brecelj, Jelka
中科院分区：
文献类型：
--
作者：
Sustar, Maja;Cvenkel, Barbara;Brecelj, Jelka
目的是研究单色和宽带刺激对光敏负反应（PhNR）振幅的影响，并比较这些刺激对青光眼患者神经节细胞损伤检测的灵敏度。41名健康受试者和16名开角型青光眼患者进行了研究。在蓝色背景下，用单色红、琥珀色、绿色和宽带白色逐渐变亮的刺激诱发视网膜电图（ERGs）。在21.6A度和27.8A度的屏幕上使用0.8A度的棋盘图案也记录了模式eeg。在对照组的光性ERGs中，红色刺激的PhNR振幅显著高于相同强度的单色琥珀色、绿色和宽频白色刺激（P < 0.01）。在青光眼患者中，PhNR对红色刺激的幅度降低百分比（68%,P < 0.001）大于对宽带刺激的幅度降低百分比（38%,P = 0.001）。红色单色刺激的PhNR比宽带刺激的PhNR（0.76）具有更大的受体工作特征曲线围合面积（0.97），是一个更敏感的参数。与宽带刺激相比，红色刺激引起的PhNR与模式ERG和视野缺损的相关性更显著（P < 0.05）。这些发现表明，与宽带刺激相比，用红色激发的PhNR可以更有效地评估神经节细胞的活性。因此，PhNR似乎是诊断神经节细胞功能障碍的一个有希望的测试。
The aim was to investigate the effects of monochromatic and broadband stimuli on the amplitude of the photopic negative response (PhNR) and to compare the sensitivities of these stimuli for the detection of ganglion cell damage in glaucoma patients. Forty-one healthy subjects were studied, along with 16 patients with open-angle glaucoma. Photopic electroretinograms (ERGs) were elicited with monochromatic red, amber, green, and broadband white stimuli of progressively brighter intensities in a blue background. Pattern ERGs were also recorded using a 0.8A degrees checkerboard pattern on a 21.6A degrees A xA 27.8A degrees screen. In the photopic ERGs of the control subjects, the PhNR amplitude was significantly higher (P < 0.01) to red than to monochromatic amber, green, and broadband white stimuli of the same intensity. In glaucoma patients, the percentage of amplitude reduction was greater for the PhNR to red (68%, P < 0.001) than to the broadband stimulus (38%, P = 0.001). The PhNR to red monochromatic stimulus appeared to be a more sensitive parameter, with a larger area enclosed by the receiver-operating characteristic curve (0.97) than for the PhNR to broadband stimulus (0.76). Also, the PhNR to red stimulus showed a more significant correlation with the pattern ERG and the visual field defects (P < 0.05) than the PhNR elicited with broadband stimulus. These findings suggest that ganglion cell activity can be more efficiently evaluated with the PhNR elicited with a red than with a broadband stimulus. The PhNR thus appears to be a promising test for the diagnostics of the ganglion cell dysfunction.