Effect of mucin production on survival in colorectal cancer: A case-control study
Effect of mucin production on survival in colorectal cancer: A case-control study
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DOI：
10.3748/wjg.14.6981
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发表时间：
2008-12-07
影响因子：
4.3
通讯作者：
Shamseddine, Ali I.
中科院分区：
文献类型：
--
作者：
Farhat, Mirna H.;Barada, Kassem A.;Shamseddine, Ali I.
目的：探讨粘液性结直肠癌(MCRC)患者与非粘液性结直肠癌(NMCRC)患者在总生存期(OS)和疾病进展时间(TTP)方面对预后的影响。方法：35例粘液性结直肠癌(MCRC)患者与35例非粘液性结直肠癌(NMCRC)患者进行年龄、性别和肿瘤分期匹配。按粘蛋白含量分为A组(50%~75%粘蛋白)、B组(75%~100%粘蛋白)、C组和对照组(50%粘蛋白)，比较各组的OS和TTP。D组包括所有粘蛋白含量为75%的肿瘤患者(对照组和A组)。结果：中位生存期：中位生存期分别为46.2mo和112.9 mo(P=0.26)。A组和B组的CS分别为70.1mo和32.8mo(P=0.46)，B组和D组的CS分别为32.8mo和70.1mo(P=0.143)。结直肠癌和非结直肠癌的TTP分别为50.17mo和44.77mo(P=0.795)。A、B、D组TTP分别为70.1、24.8、65.5mo。28%的结直肠癌患者患有低分化腺癌，而非结直肠癌患者为8.6%(P=0.028)。结论：结直肠癌患者的中位生存期和总生存期无显著降低，尤其是当粘蛋白含量为肿瘤体积的75%时。然而，它往往分化得更差。需要进行更大规模的阶段和年级匹配研究。(C)2008年《假发出版社》。版权所有。
AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). CS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularly when mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. (C) 2008 The WIG Press. All rights reserved.