THE ACTN3 R577X POLYMORPHISM IS ASSOCIATED WITH MUSCLE POWER IN MALE JAPANESE ATHLETES
THE ACTN3 R577X POLYMORPHISM IS ASSOCIATED WITH MUSCLE POWER IN MALE JAPANESE ATHLETES
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DOI：
10.1519/jsc.0000000000000338
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发表时间：
2014-07-01
影响因子：
3.2
通讯作者：
Igawa, Shoji
中科院分区：
文献类型：
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作者：
Kikuchi, Naoki;Nakazato, Koichi;Igawa, Shoji
Kikuchi， N, Nakazato， K, Min, S-k, Ueda， D和Igawa， S.日本男性运动员的ACTN3 R577X多态性与肌肉力量有关。在这项研究中，我们通过分析253名日本运动员（144名男性和109名女性）的30秒Wingate无氧测试（WAnT）中ACTN3 R577X基因型的平均和峰值功率结果，研究了ACTN3 R577X多态性是否与日本大学运动员的肌肉力量有关。每名运动员以相当于其体重7.5%的阻力进行30秒的WAnT。采用TaqMan方法对ACTN3 R577X （rs1815739）多态性进行基因分型。ACTN3 R577X基因型在人群中呈现Hardy-Weinberg平衡分布。30秒WAnT的相对和绝对平均功率结果在基因型之间无显著差异。然而，在男性运动员中，r -等位基因优势模型组的相对峰值功率结果显著高于XX组，而女性运动员中则不存在。这些结果表明，actn3r等位基因与日本男大学生运动员在比赛期间的相对能量峰值有关。
Kikuchi, N, Nakazato, K, Min, S-k, Ueda, D, and Igawa, S. The ACTN3 R577X polymorphism is associated with muscle power in male Japanese athletes. J Strength Cond Res 28 (7): 1783-1789, 2014-In this study, we investigated whether the ACTN3 R577X polymorphism is associated with muscular power in Japanese collegiate athletes by analyzing the mean and peak power results of a 30-second Wingate anaerobic test (WAnT) with respect to the ACTN3 R577X genotype in 253 Japanese athletes (144 men and 109 women). Each athlete performed a 30-second WAnT with a resistance equal to 7.5% of his or her body weight. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. The ACTN3 R577X genotypes exhibited a Hardy-Weinberg equilibrium distribution in our population. The relative and absolute mean power results of the 30-second WAnT did not differ significantly among the genotypes. However, the relative peak power result of the WAnT was significantly higher in the R-allele-dominant model groups than in the XX group in male but not female athletes. These results suggest that the ACTN3 R allele is associated with the relative peak power during the WAnT in male Japanese collegiate athletes.