World Health Organization Report: Current Crisis of Antibiotic Resistance
World Health Organization Report: Current Crisis of Antibiotic Resistance
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DOI：
10.1007/s12668-019-00658-4
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发表时间：
2019-12-01
期刊：
影响因子：
3
通讯作者：
Blatt, Nataliya L.
中科院分区：
文献类型：
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作者：
Abadi, Amin Talebi Bezmin;Rizvanov, Albert A.;Blatt, Nataliya L.
抗生素耐药性是最具挑战性的临床和公共卫生问题。尽管生活在生物医学研究的新技术时代，许多无法治愈的传染病被列为世界范围内人类死亡的主要原因。抗生素在人类和动物生产中的使用增加是医院、人类社区和动物农场出现耐药细菌的两个主要原因。目前的证据表明，导致全球抗生素危机的主要因素是卫生和健康教育计划不佳，除了临床环境中的过度处方外（主要是在更容易获得抗生素的发展中国家），以及实验室缺乏准确的诊断工具，以控制抗生素对社区广泛使用的药物的出现。听起来，在农场中使用抗体对抗有问题的细菌比用敏感的抗生素治疗它们有更多的好处。作为最佳策略，我们指出，当所有贡献者都承认他们的责任和义务，以尽量减少这一威胁人类健康的全球性问题时，抗生素耐药性危机可能会得到解决。中国和美国作为抗生素的两个主要工业化使用国，在肉类行业应该采取新的政策。目前，抗生素耐药性在世界范围内对健康构成日益严重的威胁，是许多院内感染和经常致命感染的原因。
Antibiotic resistance is the most challenging clinical and public health problem. Despite of living in the era of novel technologies in biomedical research, many of untreatable infectious diseases are ranked as the main causes of human death worldwide. Increased antibiotic use in human and use in animal production are the two major causes of emergence of resistant bacteria in hospitals, human communities, and also animal farms. Current body of evidences is indicating that major factors that led to existing crisis on antibiotics worldwide are poor educational programs on hygiene and health, inappropriate prescription in addition to the overprescription in clinical settings (mainly in developing countries with easier access to the antibiotics) and lack of accurate diagnostic tools in laboratories in order to control the emergence of antibiotics against widely used drugs in community. It sounds using the antibodies against problematic bacteria in farms has more benefits than treating them with susceptible antibiotics. As best strategy, we pointed that the crisis of antibiotic resistance may be solved when all contributors be acknowledged to their responsibilities and duties to minimize this global problem threatening the human health. China and the USA as the two main antibiotics user in industrial scale should have taken new policy in meat industry. Currently, antibiotic resistance presents a growing health threat worldwide being the cause of many nosocomial and often deadly infections.