Compensatory adrenal cortical growth is inhibited by sympathectomy.
Compensatory adrenal cortical growth is inhibited by sympathectomy.
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交感神经切除术会抑制肾上腺皮质的代偿性生长。
DOI：
10.1152/ajpendo.1985.248.2.e261
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Holzwarth,MA
中科院分区：
文献类型：
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作者：
Kleitman,N;Holzwarth,MA
手术切除一个肾上腺后，剩余的肾上腺皮质增大。这种代偿性肾上腺生长的特征是单侧肾上腺切除后72小时剩余肾上腺的重量和DNA含量增加。在这些实验中，化学交感神经切除阻止了肾上腺的代偿性生长。在新生大鼠注射6-羟基多巴胺或金刚乙胺并在40天时切除一侧肾上腺的交感神经切除后，剩余腺体的代偿性重量增加得到减弱(相对于注射赋形剂的对照组)，并且没有伴随通常的DNA含量增加。在交感神经切除和注射赋形剂的动物中，在一侧肾上腺切除后观察到RNA含量的增加；推测这反映了类固醇的增加，因为尽管失去了一侧肾上腺，大鼠仍保持了正常的血浆皮质酮和醛固酮水平(相对于假肾上腺切除组)。与对照组相比，交感神经切除手术本身并没有显著改变肾上腺重量、肾上腺核酸含量或血浆醛固酮水平；然而，血浆皮质酮水平显著降低。我们得出结论，交感神经系统参与了单侧肾上腺切除术后肾上腺皮质细胞的增殖。
After the surgical removal of one adrenal gland, the cortex of the remaining adrenal gland increases in size. This compensatory adrenal growth is characterized by increased weight and DNA content of the remaining adrenal 72 h after unilateral adrenalectomy. In these experiments, chemical sympathectomy prevented compensatory adrenal growth. In rats sympathectomized by neonatal injections of 6-hydroxydopamine or guanethidine and unilaterally adrenalectomized at 40 days of age, the compensatory increase in weight in the remaining gland was attenuated (relative to a vehicle-injected control group) and not accompanied by the usual increase in DNA content. Augmented RNA content was observed after unilateral adrenalectomy in sympathectomized as well as vehicle-injected animals; presumably this reflects increased steroidogenesis because, despite the loss of one adrenal, the rats maintained normal plasma corticosterone and aldosterone levels (relative to the sham-adrenalectomized group). The sympathectomy procedures themselves did not significantly alter adrenal weight, adrenal nucleic acid content, or plasma aldosterone relative to vehicle-injected control levels; however, plasma corticosterone levels were significantly reduced. We conclude that the sympathetic nervous system mediates the adrenal cortical cell proliferation that occurs after unilateral adrenalectomy.