Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall
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DOI：
10.1194/jlr.r800058-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Reardon, Catherine A.
中科院分区：
文献类型：
--
作者：
Getz, Godfrey S.;Reardon, Catherine A.
载脂蛋白E（apoE）由许多组织合成，包括肝脏、脑、脂肪组织和动脉壁。大多数apoE存在于与特定脂蛋白亚类相关的血浆中，并且主要来源于肝脏。然而，apoE在非肝组织中持续表达的事实表明，局部产生必须具有某些独特的功能属性。ApoE参与脂质和脂蛋白稳态的许多步骤，对于富含磷脂酰肌醇的脂蛋白和HDL。ApoE通过其由神经胶质细胞、脂肪细胞和巨噬细胞的合成对于脑、动脉壁和脂肪组织中的脂质稳态也是重要的。此外，非脂质相关的功能也归因于apoE，包括对免疫应答和炎症、氧化以及平滑肌增殖和迁移的影响。其中一些效应已被证明取决于蛋白质的不同结构域、不同浓度和脂化状态。因此，这种多功能蛋白质在多个层面上影响正常和病理生理学。Getz，G.美国，和c. a.里尔登载脂蛋白E作为血液、肝脏和动脉壁中的脂质转运和信号蛋白。J. Lipid Res. 2009. S156-S161。
Apoprotein E (apoE) is synthesized by a number of tissues including the liver, brain, adipose tissue, and artery wall. The majority of apoE is found in the plasma associated with specific lipoprotein subclasses and is derived primarily from the liver. However the fact that apoE expression is sustained in nonhepatic tissues suggests that the local production must have some unique functional attribute. ApoE is involved in many steps in lipid and lipoprotein homeostasis, for the triglyceride-rich lipoproteins and for HDL. ApoE is also important for lipid homeostasis in the brain, artery wall, and adipose tissue through its synthesis by glial cells, adipocytes, and macrophages. In addition, nonlipid related functions have also been attributed to apoE, including effects on immune response and inflammation, oxidation, and smooth muscle proliferation and migration. Some of these effects have been shown to be dependent upon different domains of the protein, different concentrations, and lipidation state. jlr Thus, this multifunctional protein impacts normal and pathophysiology at multiple levels.-Getz, G. S., and C. A. Reardon. Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall. J. Lipid Res. 2009. S156-S161.