Solid renal tumors: An analysis of pathological features related to tumor size
Solid renal tumors: An analysis of pathological features related to tumor size
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DOI：
10.1097/01.ju.0000095475.12515.5e
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发表时间：
2003-12-01
影响因子：
6.6
通讯作者：
Zincke, H
中科院分区：
文献类型：
--
作者：
Frank, I;Blute, ML;Zincke, H
目的：我们研究了实体性肾肿瘤之间肿瘤大小和恶性程度之间的关系，以及肿瘤大小和肾细胞癌（RCC）肿瘤内RCC亚型之间的关系。材料和方法：我们确定了1970年至2000年期间2,770例接受根治性肾切除术或肾单位保留手术的散发性单侧非转移性实体性肾肿瘤患者。所有病理标本均由泌尿科病理学家进行诊断，并在RCC肿瘤中进行组织学亚型和核分级。结果：良性肿瘤376例（12.8%），恶性肿瘤2,559例（87.2%）。良性肿瘤的百分比从小于1cm的46.3%下降到大于7 cm的6.3%。在肾细胞癌肿瘤中，透明细胞的百分比从小于1cm的25.6%增加到7 cm或更大的83.0%，而乳头状的百分比从小于1cm的74.4%下降到7 cm或更大的10.0%。小于1 cm的RCC肿瘤无嫌色细胞，而大于或等于7 cm的肿瘤有7.0%嫌色细胞。高级别RCC恶性肿瘤的百分比从小于1 cm的2.3%增加到7 cm或更大的RCC肿瘤的57.7%。只有1%的所有肿瘤小于1厘米和9.2%的所有肿瘤小于2厘米是高级别malignancy.Conclusions：随着肿瘤大小的增加有一个恶性肿瘤的几率显着增加相比，良性肿瘤，透明细胞相比，乳头状肾细胞癌和高级别相比，低级别恶性肿瘤。
Purpose: We examined the relationship between tumor size and malignancy among solid renal tumors, and the relationship between tumor size and RCC subtype within tumors with renal cell carcinoma (RCC).Materials and Methods: We identified 2,770 adult patients who underwent radical nephrectomy or nephron sparing surgery for sporadic unilateral nonmetastatic solid renal tumors between 1970 and 2000. All pathology specimens were reviewed by a urological pathologist for diagnosis, and in RCC tumors, for histological subtype and nuclear grade.Results: There were 376 benign (12.8%) and 2,559 (87.2%) malignant tumors. The percentage of benign tumors decreased from 46.3% for those less than 1 cm to 6.3% for those 7 cm or greater. Among RCC tumors the percentage that were clear cell increased from 25.6% for those less than 1 cm to 83.0% for tumors 7 cm or greater, while the percentage that were papillary decreased from 74.4% for those less than 1 cm to 10.0% for tumors 7 cm or greater. No RCC tumors less than 1 cm were chromophobe compared to 7.0% of tumors 7 cm or greater. The percentage of malignant tumors that were high grade RCC increased from 2.3% for those less than 1 cm to 57.7% for RCC tumors 7 cm or greater. Only 1% of all tumors less than 1 cm and 9.2% of all tumors less than 2 cm were high grade malignancies.Conclusions: As tumor size increased there was a significant increase in the odds of having a malignant compared to a benign tumor, clear cell compared to papillary RCC and high grade compared to low grade malignancy.