Chromosome findings in effusions from patients with Hodgkin's disease
Chromosome findings in effusions from patients with Hodgkin's disease
复制标题
霍奇金病患者积液中的染色体发现
DOI：
10.1002/ijc.2910210204
复制
发表时间：
1978
影响因子：
6.4
通讯作者：
C. Schmidt
中科院分区：
文献类型：
--
作者：
D. Hossfeld;C. Schmidt
对6例晚期霍奇金病患者的积液细胞进行了研究。尽管在6例病例中有5例没有霍奇金细胞或里德-斯特恩伯格细胞，但在所有积液中都发现了显著的克隆性染色体异常，包括一些复发性标记染色体。结论核型异常的积液细胞与何杰金氏病的发病密切相关。
Effusion cells from six patients with advanced Hodgkin's disease were studied. Even though no Hodgkin or Reed‐Sternberg cells could be identified cytologically in five of the six cases, striking chromosome anomalies of a clonal nature, including a number of recurrent marker chromosomes, were demonstrated in all effusions. It is concluded that the effusion cells with abnormal karyotypes were intimately related to the pathogenesis of Hodgkin's disease.