Identifcation of a novel C6 protein encoded by tomato leaf curl China virus
Identifcation of a novel C6 protein encoded by tomato leaf curl China virus
复制标题
番茄曲叶病毒编码的新型C6蛋白的鉴定
DOI：
10.1186/s42483-022-00151-z
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发表时间：
2022
影响因子：
3.4
通讯作者：
Zhou xueping
中科院分区：
文献类型：
--
作者：
Wang zhiyuan;Wang yaqin;Rosa Lozano-Duran;Hu tao;Zhou xueping
菜豆花叶病毒在世界范围内对许多农作物造成了严重的危害，对菜豆花叶病毒编码的一些非经典蛋白的研究已经取得了很大进展。本研究在感染中国番茄曲叶病毒（ToLCCNV）的本氏烟草（Nicotiana benthamiana）植株中检测到一种新的病毒蛋白C6。序列分析表明，C6 ORF位于已报道的约36%的菜豆花叶病毒序列的互补链上，且氨基酸序列保守。ToLCCNV C6特异性定位于线粒体。对缺失突变体的分析表明，C6具有内部线粒体靶向信号。总的来说，这些数据揭示了一种新的菜豆花叶病毒编码的蛋白质靶向不同的植物细胞器。
Begomoviruses cause significant losses to a wide range of crops worldwide, and a great progress has been made in characterizing some noncanonical proteins encoded by begomoviruses. In the present study, a novel viral protein, C6, was detected in Nicotiana benthamiana plants infected with tomato leaf curl China virus (ToLCCNV). Sequence analyses revealed that the C6 ORF is on the complementary strand of approximately 36% reported begomovirus sequences with conserved amino acid sequence. ToLCCNV C6 specifically localizes to mitochondria. Analysis of deletion mutants showed that C6 possesses an internal mitochondrial targeting signal. Overall, these data uncover a novel begomovirus-encoded protein targeting distinct plant cell organelles.