A SEROLOGICAL DIFFERENTIATION OF HUMAN AND OTHER GROUPS OF HEMOLYTIC STREPTOCOCCI.
A SEROLOGICAL DIFFERENTIATION OF HUMAN AND OTHER GROUPS OF HEMOLYTIC STREPTOCOCCI.
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人类和其他溶血链球菌的血清学分化。
DOI：
10.1084/jem.57.4.571
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发表时间：
1933-03-31
影响因子：
15.3
通讯作者：
Lancefield, R C
中科院分区：
文献类型：
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作者：
Lancefield, R C
1. 从人、其他动物、牛奶和奶酪中分离出的106株溶血性链球菌中，除两株外，其余的都被分为五组，这与培养源有明确的关系。这些广泛的群体可以通过其他地方讨论的方法细分为特定的类型。通过使用两种特殊试剂，可以实现特定的类群分类：(a)用热盐酸处理细菌制备的提取物，(b)用正式培养物免疫的动物血清。凝集反应检测不到这种分化。该分组与其他研究人员在文化和生化特征的基础上所描述的一致。2. 在A组菌株中存在的群体特异性物质在化学性质上被确定为碳水化合物。其他基团的特异性所依赖的特定物质的化学组成尚未确定。然而，似乎并非不可能的是，它们都可能属于碳水化合物的一般类别，每种碳水化合物在化学上都是不同的，在血清学上都是特定的。
1. All except two of 106 strains of hemolytic streptococci isolated from man, other animals, milk, and cheese have been classified into five groups, which bear a definite relationship to the sources of the cultures. These broad groups may be subdivided into specific types by methods discussed elsewhere. The specific group classification is made possible by employing two special reagents: (a) extracts prepared by treatment of the bacteria with hot hydrochloric acid, and (b) serum of animals immunized with formalinized cultures. This differentiation is not detected by the agglutination reaction. The grouping agrees with that described by other investigators on the basis of cultural and biochemical characteristics. 2. The group-specific substance present in strains of Group A has been identified chemically as carbohydrate in nature. The chemical composition of the specific substances upon which the specificity of the other groups depends has not been determined. It seems not unlikely, however, that all of them may belong in the general class of carbohydrates, each being chemically distinct and serologically specific in the individual groups.