Is there a role for neurotrophin treatment of the ocular surface following laser in situ keratomileusis (LASIK)?
Is there a role for neurotrophin treatment of the ocular surface following laser in situ keratomileusis (LASIK)?
复制标题
激光原位角膜磨镶术 (LASIK) 后神经营养蛋白对眼表的治疗有作用吗？
DOI：
10.1016/j.ajo.2005.03.064
复制
发表时间：
2005
影响因子：
4.2
通讯作者：
JohnsonJr,EugeneM
中科院分区：
文献类型：
--
作者：
Pepose,JayS;JohnsonJr,EugeneM
KERATOMILEUSIS (LASIK): In this issue of THE JOURNAL, Kim and associates 1 report on nerve growth factor (NGF) in tears after (LASIK). Tear dysfunction may, arguably, represent the most common unwanted sequela of excimer laser vision correction. 2 Following LASIK, dry eye symptoms, such as dryness and foreign body sensation, are frequent. Studies show an increase in prevalence of dry eye symptoms from 38% preoperatively to 69% to 85% during the first few weeks post-LASIK. 2, 3 Ocular irritation scores can remain elevated for up to 12 to 16 months. 3, 4 In contrast, studies indicate that non-flap associated forms of excimer laser surface ablation, such as, photorefractive keratectomy (PRK) or laser-assisted sub-epithelial keratectomy (LASEK), may elicit less dry eye symptoms, tear film instability, corneal barrier dysfunction, and corneal hypesthesia compared with LASIK for an equivalent laser ablation depth. 5, 6Post-LASIK dry eye has some features that help to differentiate it from the typical non-LASIK patient with low aqueous tear production. Post-LASIK dry eye patients more frequently complain of blurring or ghosting of vision, only very transiently relieved with artificial tears, with symptoms frequently worse upon awakening. In patients without pre-existing sicca syndrome, the Schirmer test may be near normal or only slightly lower than preoperative values. A punctate epithelial keratopathy can be present, which is typically centrally located within the confines of the flap, in contrast with the more inferior pattern more commonly seen in the non-LASIK patient
