Washout measurement of radioisotope implanted by radioactive beams in the rabbit
Washout measurement of radioisotope implanted by radioactive beams in the rabbit
复制标题
DOI：
10.1088/0031-9155/48/15/302
复制
发表时间：
2003-08-07
影响因子：
3.5
通讯作者：
Ishii, K
中科院分区：
文献类型：
--
作者：
Mizuno, H;Tomitani, T;Ishii, K
本文研究了放射性核素C-10和C-11在家兔脑和股肌内的清除。在重离子治疗的射程验证系统或三维体成像中，生物体中的生物冲刷效应是重要的。将正电子发射器束植入家兔体内，并通过原位正电子照相机测量湮灭伽马射线，该照相机由设置在靶两侧的一对闪烁照相机组成。将感兴趣区（ROI）设置为二维位置分布，并测量ROI的时间-活性曲线。实验在两种情况下进行：活的和死的。通过对两组测量数据的比较，推断出冲刷过程中至少有三个分量。三分量模型分析清楚地解释了大脑和大腿肌肉的时间-活动曲线。脑的三种组分比率（和洗脱半衰期）分别为35%（2.0 s）、30%（140 s）和35%（10 191 s），大腿肌肉为30%（10 s）、19%（195 s）和52%（3175 s）。在通过正电子相机测量验证治疗计划时必须考虑冲洗效应。
Washout of C-10 and C-11 implanted by radioactive beams in brain and thigh muscle of rabbits was studied. The biological washout effect in a living body is important in the range verification system or three-dimensional volume imaging in heavy ion therapy. Positron emitter beams were implanted in the rabbit and the annihilation gamma-rays were measured by an in situ positron camera which consisted of a pair of scintillation cameras set on either side of the target. The ROI (region of interest) was set as a two-dimensional position distribution and the time-activity curve of the ROI was measured. Experiments were done under two conditions: live and dead. By comparing the two sets of measurement data, it was deduced that there are at least three components in the washout process. Time-activity curves of both brain and thigh muscle were clearly explained by the three-component model analysis. The three components ratios (and washout half-lives) were 35% (2.0 s), 30% (140 s) and 35% (10 191 s) for brain and 30% (10 s), 19% (195 s) and 52% (3175 s) for thigh muscle. The washout effect must be taken into account for the verification of treatment plans by means of positron camera measurements.