Fluvoxamine treatment of obsessive-compulsive disorder.
Fluvoxamine treatment of obsessive-compulsive disorder.
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氟伏沙明治疗强迫症。
DOI：
10.1176/ajp.144.12.1543
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
R. Dar
中科院分区：
文献类型：
--
作者：
T. Perse;J. Greist;J. Jefferson;R. Rosenfeld;R. Dar
16 名符合 DSM-III 强迫症标准的门诊患者完成了为期 20 周的氟伏沙明和安慰剂双盲交叉试验。 13 名 (81%) 患者服用氟伏沙明后病情有所改善，而 3 名患者 (19%) 服用安慰剂后病情有所改善。氟伏沙明治疗与强迫症状、焦虑和抑郁症状的显着改善相关。抑郁症受试者强迫措施的改善与抑郁症状的改善相关。非抑郁症受试者的强迫症状指标也有所改善。在这项试验中，氟伏沙明是治疗强迫症的有效且安全的方法。
Sixteen outpatients who met DSM-III criteria for obsessive-compulsive disorder completed a 20-week double-blind, crossover trial with fluvoxamine and placebo. Thirteen (81%) improved with fluvoxamine, while three (19%) improved with placebo. Fluvoxamine treatment was associated with significant improvement on measures of obsessive-compulsive symptoms, anxiety, and depression. Depressed subjects' improvement on obsessive-compulsive measures correlated with improvement in symptoms of depression. Nondepressed subjects also showed improvement on measures of obsessive-compulsive symptoms. In this trial, fluvoxamine was an effective and safe treatment for obsessive-compulsive disorder.