A prospective study of micronutrient status in adolescent pregnancy
A prospective study of micronutrient status in adolescent pregnancy
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DOI：
10.3945/ajcn.2008.27097
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发表时间：
2009-04-01
影响因子：
7.1
通讯作者：
Poston, Lucilla
中科院分区：
文献类型：
--
作者：
Baker, Philip N.;Wheeler, Simon J.;Poston, Lucilla
背景：青少年比成年人更有可能食用能量密集、缺乏微量营养素的饮食，并经历不利的妊娠结局。目的：目的：前瞻性评估参加关于青少年饮食(ATE)研究的怀孕青少年的微量营养素摄入量和血液生物标记物，并确定与妊娠结局的关系。设计：从2个英国市中心人口中招募怀孕青少年(n=500)。通过三次24小时饮食召回来评估膳食摄入量，并通过测量妊娠晚期血液生物标记物来评估微量营养素状况。妊娠结局包括小于胎龄儿(SGA)出生和早产。结果：铁和叶酸的中位数摄入量低于英国和美国的推荐量。吸烟者的叶酸和维生素B-12水平较低，尽管饮食摄入量没有差异。12%的受试者血清叶酸为7.0nmol/L，20%的受试者血清总同型半胱氨酸(THcy)升高(10mU/L)。52%的受试者患有缺铁性贫血，30%的受试者血清25-羟基维生素D浓度
Background: Adolescents are more likely than adults to consume energy-dense, micronutrient-poor diets and to experience adverse pregnancy outcomes.Objectives: The objectives were to assess micronutrient intake and blood biomarkers prospectively in pregnant adolescents recruited to the About Teenage Eating (ATE) Study and to determine associations with pregnancy outcome.Design: Pregnant adolescents (n = 500) were recruited from 2 UK inner city populations. Dietary intake was assessed with three 24-h dietary recalls, and micronutrient status was assessed by measurement of third trimester blood biomarkers. Pregnancy outcomes included small-for-gestational age (SGA) birth and preterm delivery.Results: Median iron and folate intakes were lower than UK and US recommended amounts. Folate and vitamin B-12 status were lower in smokers, despite no differences in dietary intake. Serum folate was,7.0 nmol/L in 12% of subjects, and serum total homocysteine (tHcy) was elevated (>10 mu mol/L) in 20% of subjects. Fifty-two percent of the subjects had iron deficiency anemia, and 30% had serum 25-hydroxyvitamin D concentrations