Synthesis and herbicidal activity of phenyl-substituted benzoylpyrazoles
Synthesis and herbicidal activity of phenyl-substituted benzoylpyrazoles
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DOI：
10.1002/ps.588
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发表时间：
2002-12-01
影响因子：
4.1
通讯作者：
Weimer, MR
中科院分区：
文献类型：
--
作者：
Siddall, TL;Ouse, DG;Weimer, MR
合成了一系列新型的取代3-苯基苯甲酰基吡唑类除草剂。通过三种新开发的合成路线制备目标材料，从而可以全面研究该系列的SAR（构效关系）。在苯环的4-位上具有烷氧基的情况下，获得了禾本科杂草活性（野燕麦、狗尾草（L）Beauv和大穗看麦娘）和小麦选择性的最佳组合。活性通过吡唑上的叔丁基和苯甲酰基部分的C-2位上的甲基的存在而进一步增强。烷氧基取代的3-苯基苯甲酰基吡唑类除草剂是一类具有潜在应用价值的禾本科重要杂草除草剂。(C)2002年，化学工业协会。
A novel series of substituted 3-phenyl benzoylpyrazoles were prepared and tested as potential grass herbicides. The targeted materials were prepared by three newly developed synthetic routes, which allowed a comprehensive study of the SAR (structure-activity relationships) of this series. The best combination of grass weed activity (Avena fatua L, Setaria viridis (L) Beauv and Allopecurus myosuroides Huds) and wheat selectivity was obtained with an alkoxy group in the 4-position of the phenyl ring. Activity was further enhanced by the presence of tert-butyl on the pyrazole and a methyl group at the C-2 position of the benzoyl moiety. The alkoxy-substituted 3-phenylbenzoylpyrazoles are a novel class of herbicides with potential utility for control of important grass weeds in cereals. (C) 2002 Society of Chemical Industry.