HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
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DOI：
10.1006/cyto.2002.0890
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发表时间：
2002-05-21
期刊：
影响因子：
3.8
通讯作者：
Ghezzi, P
中科院分区：
文献类型：
--
作者：
Agnello, D;Wang, HC;Ghezzi, P
高迁移率族蛋白-1（HMG-1，也称为HMGB-1）是一种DNA结合蛋白，调节基因转录和稳定核小体形成。HMG-1最近被认为是一种细胞因子，因为它是内毒素致死性的迟效介质，诱导单核细胞释放促炎细胞因子。这里显示，将HMG-1施用到脑室中减少了食物摄入（对照中食物摄入= 4.6g/小鼠，而1 μ g HMG-1 i. c. v.后食物摄入= 1.6g/小鼠; P
High-mobility group protein-1 (HMG-1 also termed HMGB-1), a DNA-binding protein, regulates gene transcription and stabilizes nucleosome formation. HMG-1 was recently implicated as a cytokine, because it is a late-acting mediator of endotoxin lethality that induces the release of pro-inflammatory cytokines from monocytes. Here it is shown that administration of HMG-1 into the cerebral ventricles decreases food intake (food intake=4.6 g/mouse in controls vs 1.6 g/mouse after 1 mug HMG-1 i.c.v.; P