Functional Connectivity Hubs and Networks in the Awake Marmoset Brain.
Functional Connectivity Hubs and Networks in the Awake Marmoset Brain.
复制标题
醒着的马尔莫斯脑大脑中的功能连接枢纽和网络。
DOI：
10.3389/fnint.2016.00009
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发表时间：
2016
影响因子：
3.5
通讯作者：
Tomasi D
中科院分区：
文献类型：
--
作者：
Belcher AM;Yen CC;Notardonato L;Ross TJ;Volkow ND;Yang Y;Stein EA;Silva AC;Tomasi D
In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or “hubs”, and we have recently proposed local functional connectivity density (lFCD) mapping to identify highly-connected nodes in the human brain. Here, we imaged awake nonhuman primates to test whether, like the human brain, the marmoset brain contains FC hubs. Ten adult common marmosets (Callithrix jacchus) were acclimated to mild, comfortable restraint using individualized helmets. Following restraint training, resting BOLD data were acquired during eight consecutive 10 min scans for each subject. lFCD revealed prominent cortical and subcortical hubs of connectivity across the marmoset brain; specifically, in primary and secondary visual cortices (V1/V2), higher-order visual association areas (A19M/V6[DM]), posterior parietal and posterior cingulate areas (PGM and A23b/A31), thalamus, dorsal and ventral striatal areas (caudate, putamen, lateral septal nucleus, and anterior cingulate cortex (A24a). lFCD hubs were highly connected to widespread areas of the brain, and further revealed significant network-network interactions. These data provide a baseline platform for future investigations in a nonhuman primate model of the brain’s network topology.
