Bio-hybrid tactile sensor for the study of the role of mechanoreceptors in human tactile perception
Bio-hybrid tactile sensor for the study of the role of mechanoreceptors in human tactile perception
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DOI：
10.1016/j.mee.2012.03.009
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发表时间：
2012-09-01
影响因子：
2.3
通讯作者：
Anthony, C. J.
中科院分区：
文献类型：
--
作者：
Cheneler, D.;Ward, M. C. L.;Anthony, C. J.
在本文中，描述了生物混合触觉传感器的设计和制造。该装置旨在将细胞培养物和生物组织的活力维持足够长的时间，以便在通常的非理想条件下进行实验。这是通过确保细胞有足够的营养、氧气和热量来实现的。它具有开放式配置，并配备了对细胞外基质中离子浓度变化敏感的局部电导率传感器。这允许在将接触应力施加到组织表面的同时监测从细胞输出的离子形式的第二信使。还描述了初始实验，其中将局部电导率传感器浸入哺乳动物细胞中常见的不同浓度的不同盐的溶液中。使用复杂的映射对传感器响应进行分析建模，从而产生详细说明传感器灵敏度的表达式。在哺乳动物细胞中发现的浓度下，我们发现该传感器可以检测溶液中小至 0.25 μM 的氯化钾浓度变化。(C) 2012 Elsevier B.V. 保留所有权利。
In this paper, the design and fabrication of a bio-hybrid tactile sensor is described. The device is designed to sustain the viability of cell-cultures and biological tissues for sufficient time as to allow experimentation in ordinarily non-ideal conditions. This is achieved by ensuring the cells have sufficient nutrients, oxygen and heat. It has an open configuration and is equipped with a local conductivity sensor which is sensitive to variations in the ion concentrations in the extracellular matrix. This allows secondary messengers in the form of the ion output from the cells to be monitored whilst contact stresses are applied to the tissue surface. Initial experiments are also described whereby the local conductivity sensor is submerged in solutions of various concentrations of different salts commonly found in mammalian cells. The sensor response is modelled analytically using complex mapping which lead to expressions detailing the sensitivity of the sensor. At concentrations found in mammalian cells, it was found that the sensor can detect changes in concentration of potassium chloride in solution as small as 0.25 mu M. (C) 2012 Elsevier B.V. All rights reserved.