MOUSE STRAIN IDENTIFICATION
MOUSE STRAIN IDENTIFICATION
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DOI：
10.1038/238351a0
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发表时间：
1972-01-01
期刊：
影响因子：
64.8
通讯作者：
FESTING, M
中科院分区：
文献类型：
--
作者：
FESTING, M
自1909年以来，INBRED品系的小鼠已被广泛使用，目前已识别出200多种不同的品系或亚品系2。然而，在实践中，尽管每种菌株都有一套独特的特征，如平均寿命、肿瘤发病率、行为、生殖能力和血型，但不同的菌株在形态上可能无法区分。因此，例如，几种广泛使用的近交白化病品系不能轻易地与更常见的随机培育的白化病品系区分开来。不幸的是，尽管已经开发了用于菌株鉴定的简化的生物化学方法3，但是它们仍然太昂贵和费力。
INBRED strains of mice have been widely used since 1909, and more than 200 distinct strains or sub-strains are now recognized2. In practice, however, although each strain has a unique set of characteristics such as mean life-span, tumour incidence, behaviour, reproductive performance and blood group, different strains may be morphologically indistinguishable. Thus, for example, several of the widely used inbred albino strains cannot easily be told apart from the more common albino randomly bred strains. Unfortunately, although simplified biochemical methods for strain identification have been developed3, they are still too costly and laborious.