Plasticity of the corticospinal tract in early blindness revealed by quantitative analysis of fractional anisotropy based on diffusion tensor tractography
Plasticity of the corticospinal tract in early blindness revealed by quantitative analysis of fractional anisotropy based on diffusion tensor tractography
复制标题
基于扩散张量纤维束成像的分数各向异性定量分析揭示早期失明时皮质脊髓束的可塑性
DOI：
10.1016/j.neuroimage.2007.03.003
复制
发表时间：
2007-06-01
期刊：
影响因子：
5.7
通讯作者：
Li, Kuncheng
中科院分区：
文献类型：
--
作者：
Yu, Chunshui;Shu, Ni;Li, Kuncheng
早期视觉剥夺可能不仅在视觉系统中，还在其余感觉系统中诱发可塑性变化，这是由于在这些未受损的感觉模式中经验改变所致。先前的大多数研究集中在感觉模式的皮质区域的可塑性上，但对运动系统和白质纤维束的可塑性关注较少。我们的目的是通过基于纤维束的分数各向异性（FA）定量分析来研究早期失明者皮质脊髓束（CST）的可塑性。对17名早期失明者和17名性别及年龄匹配的有视力的受试者进行了扩散张量成像。重建了每个受试者的整个皮质脊髓束，并分析了该纤维束的平均FA值。为了验证从整个皮质脊髓束得出的结果，我们进一步分析了大脑脚最低层面和侧脑室最高层面之间的一段皮质脊髓束，在该区域纤维排列连贯，且不同受试者之间皮质脊髓束的解剖对应关系得以确定。与匹配的有视力的参与者相比，早期失明男性的皮质脊髓束平均FA值显著增加，而早期失明女性则没有。总之，皮质脊髓束的可塑性存在于早期失明男性中，这可能与皮质脊髓束关键发育时期运动经验的改变有关。这项研究还支持这样一种观点，即经验依赖性可塑性不仅发生在皮质区域，也发生在白质纤维束中。（c）2007爱思唯尔公司。保留所有权利。
Early visual deprivation may induce plastic changes, not only in the visual system, but also in the remaining sensory systems, secondary to altered experience in these spared modalities. Most of previous studies were focused on the plasticity of cortical areas of sensory modalities, but little attention was paid to the plasticity of motor system and white matter fiber tracts. Our purpose is to investigate the plasticity of the corticospinal tract (CST) in early blindness by tract-based quantitative analysis of fractional anisotropy (FA). Diffusion tensor imaging was performed in 17 early blind and 17 gender- and age-matched sighted subjects. The entire CST of each subject was reconstructed and the average FA of the tract was analyzed. To validate the results derived from the entire CST, we further analyzed a segment of the CST between the lowest slice of the cerebral peduncle and the uppermost slice of the lateral ventricle, in which the fibers are coherently arranged and the anatomical correspondence of the CST across subjects is established. On comparison with matched sighted participants, the average FA of the CST was significantly increased in the early blind men, but not in the early blind women. In conclusion, the plasticity of the CST is present in the early blind men, which might be related to the changes of motor experience during critical developmental period of the CST. This study also supports the perspective that experience-dependent plasticity occurs not only, in the cortical areas but also in the white matter fiber tracts. (c) 2007 Elsevier Inc. All rights reserved.