Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.
Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.
复制标题
%20比%2040%%20的%20%20simian%20病毒%2040%20大%20T抗原编码%20序列%20是%20转化所需的%20。
DOI：
10.1128/mcb.4.8.1661-1663.1984
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发表时间：
1984
影响因子：
5.3
通讯作者：
Danna,KJ
中科院分区：
文献类型：
--
作者：
Sompayrac,L;Danna,KJ
F8 d1是猴病毒40早期区域缺失突变体，其缺少猴病毒40 DNA序列，在0.168和0.424图单位之间。尽管有这种大的缺失，克隆的F8 dlDNA转化Fisher大鼠F111细胞和BALB/3 T3克隆A31小鼠细胞的效率与克隆的猿猴病毒40野生型DNA一样。这些结果表明，有效转化需要小于40%的大T抗原编码序列。
F8dlis a simian virus 40 early-region deletion mutant that lacks the simian virus 40 DNA sequences between 0.168 and 0.424 map units. Despite this large deletion, cloned F8dlDNA transforms Fisher rat F111 cells and BALB/3T3 clone A31 mouse cells as efficiently as does cloned simian virus 40 wild-type DNA. These results indicate that less than 40% of the large T-antigen-coding sequence is required for efficient transformation.