Total Synthesis of Asterredione
Total Synthesis of Asterredione
复制标题
紫菀二酮的全合成
DOI：
10.1021/jo4028177
复制
发表时间：
2014
影响因子：
3.6
通讯作者：
Hu Xiangdong
中科院分区：
文献类型：
--
作者：
Gai Sinan;Zhang Qing;Hu Xiangdong
首次完成了紫菀二酮的全合成，经过五步线性反应，总收率为21.5%。作为关键的一步，利用本实验室开发的Darfening/扩环策略，很容易地获得了紫菀二酮的2-季-1，3-环戊烯二酮骨架。所合成的紫菀二酮的结构经X-射线衍射完全确证。
The first total synthesis of asterredione was efficiently accomplished over five linear steps and in 21.5% overall yield. As the crucial step, the 2-quaternary 1,3-cyclopentenedione skeleton of asterredione was readily achieved using the Darzens/ring-expansion strategy developed in our laboratory. The structure of synthesized asterredione was fully confirmed by X-ray crystallography.