β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway
β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway
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DOI：
10.1016/j.neures.2013.03.016
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发表时间：
2013-07-01
影响因子：
2.9
通讯作者：
Tooyama, Ikuo
中科院分区：
文献类型：
--
作者：
Kameshima, Naoko;Yanagisawa, Daijiro;Tooyama, Ikuo
我们检查了用碘 125 (I-125-A beta 40) 标记的人 β-淀粉样 (1-40) 肽注射到大鼠脑室或尾静脉后的分布模式。在接受静脉注射的大鼠中，鼻区 I-125-A beta 40 的放射性浓度与其他颅外器官相似。相比之下，接受脑室内注射的大鼠鼻区尾部显示出高水平的 I-125-A β 40 放射性。这些结果表明 Aβ 通过非血液途径从大脑到达鼻腔。 (c) 2013 年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
We examined the distribution patterns of human beta-amyloid (1-40) peptide labeled with iodine 125 (I-125-A beta 40) after injections into the cerebral ventricle or tail vein of rats. In rats receiving an intravenous injection, the radioactive concentration of I-125-A beta 40 in the nasal area was similar to other extracranial organs. In contrast, the caudal part of the nasal area in rats receiving an intracerebroventricular injection displayed a high level of I-125-A beta 40 radioactivity. These results suggest that A beta reaches the nasal cavity from the brain via a non-blood pathway. (c) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.