Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation.
Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation.
复制标题
肾毒性氨基酸和谷胱甘肽 S-结合物：形成和肾激活。
DOI：
10.1007/978-1-4684-5134-4_43
复制
发表时间：
1986
影响因子：
--
通讯作者：
Elfarra,AA
中科院分区：
文献类型：
--
作者：
Anders,MW;Lash,LH;Elfarra,AA
化学品产生组织损伤的机制包括，例如，生物转化为反应性的亲电代谢物，脂质过氧化反应的启动，以及有毒的还原氧代谢物的形成。肝脏由于其丰富的生物转化能力，经常是其毒性与生物活化有关的化学品的靶器官。肝外靶器官是众所周知的，这种毒性也可能与靶器官生物活化有关。
The mechanisms by which chemicals produce tissue damage include, for example, biotransformation to reactive, electrophilic metabolites, initiation of lipid peroxidation, and formation of toxic, reduced oxygen metabolites. The liver, because of its abundant capacity for biotransformation, is frequently the target organ for chemicals whose toxicity is associated with bioactivation. Extrahepatic target organs are well known, and this toxicity may also be associated with target organ bioactivation.