The NMDA receptor participates in respiration-related mitral cell synchrony
The NMDA receptor participates in respiration-related mitral cell synchrony
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DOI：
10.1007/s002210050273
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发表时间：
1998-01-01
影响因子：
2
通讯作者：
Brunjes, PC
中科院分区：
文献类型：
--
作者：
Philpot, BD;Lyders, EM;Brunjes, PC
N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体参与嗅球二尖瓣细胞的兴奋，并在颗粒细胞介导的反馈抑制中起重要作用。在本研究中，在体内进行细胞外单位记录，以证明非竞争性NMDA受体拮抗剂MK-801外周给药不影响二尖瓣细胞的放电率。然而，虽然超过50%的气味驱动的二尖瓣细胞活性通常与呼吸周期相关，但在MK-801给药后30分钟，仅约10%的二尖瓣细胞活性与呼吸周期相关。因此，NMDA受体是正常呼吸相关的二尖瓣细胞活动的参与者，并可能在编码嗅觉信息的灯泡振荡的形成中发挥重要作用。此外，NMDA受体能够介导依赖于同步活动的灯泡中的活动依赖性变化。
The N-methyl-D-aspartate (NMDA)-type glutamate receptor participates in the excitation of olfactory bulb mitral cells and is important in granule-cell-mediated feedback-inhibition In the present study, extracellular unit recordings were made in vivo to demonstrate that the firing rates of mitral cells are not affected by peripheral administration of the non-competitive NMDA receptor antagonist MK-801. However, while over 50% of odor-driven mitral cell activity is normally correlated with the respiratory cycle, only about 10% of mitral cell activity is correlated with the respiratory cycle 30 min after MK-801 administration. Thus, the NMDA receptor is a participant in normal respiration-related mitral cell activity and may have an important role in the formation of bulb oscillations that encode olfactory information. Furthermore, the NMDA receptor is in a position to mediate activity-dependent changes in the bulb that rely on synchronous activity.