Optical imaging of metastatic tumors using a folate-targeted fluorescent probe
Optical imaging of metastatic tumors using a folate-targeted fluorescent probe
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DOI：
10.1117/1.1609453
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发表时间：
2003-10-01
影响因子：
3.5
通讯作者：
Low, PS
中科院分区：
文献类型：
--
作者：
Kennedy, MD;Jallad, KN;Low, PS
我们描述了使用肿瘤靶向配体，维生素叶酸，提供一个附加的荧光探针，原发性和转移性肿瘤过表达叶酸受体。在激光激发时，正常组织的衍生图像通常显示很少或没有荧光，而表达叶酸受体的肿瘤的图像显示明亮的荧光，其可以容易地与相邻的正常组织区分开。此外，亚毫米大小的转移性肿瘤位点也可以在没有图像处理或增强的帮助下可视化。该技术提供的肿瘤和正常组织之间的明显区别可以应用于手术期间肿瘤组织的定位和切除或增强的内窥镜检测和癌症分期。(C)2003年，由光学仪器工程师学会（Society of Photo-Optical Instrumentation Engineers）主办。
We describe the use of a tumor targeting ligand, the vitamin folic acid, to deliver an attached fluorescent probe to both primary and metastatic tumors overexpressing the folate receptor. Upon laser excitation, derived images of normal tissues generally show little or no fluorescence, whereas images of folate receptor-expressing tumors display bright fluorescence that can be easily distinguished from adjacent normal tissue. Furthermore, metastatic tumor loci of submillimeter size can also be visualized without the aid of image processing or enhancement. The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers. (C) 2003 Society of Photo-Optical Instrumentation Engineers.