Properties of sympathetic reflexes elicited by natural vestibular stimulation: implications for cardiovascular control.
Properties of sympathetic reflexes elicited by natural vestibular stimulation: implications for cardiovascular control.
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DOI：
10.1152/jn.1994.71.6.2087
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发表时间：
1994-06
影响因子：
2.5
通讯作者：
B. J. Yates;Alan D. Miller
中科院分区：
文献类型：
--
作者：
B. J. Yates;Alan D. Miller
1.为了研究前庭交感神经反射的特性，我们在去大脑猫的多个垂直平面上记录了自然前庭刺激时内脏神经的流出。大多数动物被小脑切除，尽管在小脑完整的制备物中记录了一些反应。前庭刺激产生的旋转头的动物，其上颈部背根被切断，以消除输入从颈部感受器;压力感受器去神经和迷走神经切断术也被执行，以消除内脏输入。2.在0.2-0.5 Hz下测量产生内脏神经活动（响应向量方向）的最大调制的头部旋转平面。然后用与此方向一致的正弦（0.05- 1-Hz）刺激研究响应的动力学。3.通常情况下，内脏神经流出的最大调制引起的头部旋转在一个平面附近的间距;鼻子向上旋转产生增加流出和鼻子向下旋转减少神经放电。增益的反应保持相对恒定的刺激频率和相位一致的刺激位置附近，像定期发射耳石传入。在小脑切除和小脑完整的动物中记录到类似的反应动力学。4.内脏神经对头部旋转的反应可以通过将兴奋性毒素红藻氨酸微量注射到前庭内侧核和下核中而被消除，这与前庭受体激活所产生的反应是一致的。5.从内脏神经记录的前庭交感神经反射的特性支持前庭系统参与补偿姿势相关的血压变化的假设。
1. To study the properties of vestibulosympathetic reflexes we recorded outflow from the splanchnic nerve during natural vestibular stimulation in multiple vertical planes in decerebrate cats. Most of the animals were cerebellectomized, although some responses were recorded in cerebellum-intact preparations. Vestibular stimulation was produced by rotating the head in animals whose upper cervical dorsal roots were transected to remove inputs from neck receptors; a baroreceptor denervation and vagotomy were also performed to remove visceral inputs. 2. The plane of head rotation that produced maximal modulation of splanchnic nerve activity (response vector orientation) was measured at 0.2-0.5 Hz. The dynamics of the response were then studied with sinusoidal (0.05- to 1-Hz) stimuli aligned with this orientation. 3. Typically, maximal modulation of splanchnic nerve outflow was elicited by head rotations in a plane near pitch; nose-up rotations produced increased outflow and nose-down rotations reduced nerve discharges. The gains of the responses remained relatively constant across stimulus frequencies and the phases were consistently near stimulus position, like regularly firing otolith afferents. Similar response dynamics were recorded in cerebellectomized and cerebellum-intact animals. 4. The splanchnic nerve responses to head rotation could be abolished by microinjections of the excitotoxin kainic acid into the medial and inferior vestibular nuclei, which is concordant with the responses resulting from activation of vestibular receptors. 5. The properties fo vestibulosympathetic reflexes recorded from the splanchnic nerve support the hypothesis that the vestibular system participates in compensating for posturally related changes in blood pressure.