Physical, Psychological, and Functional Comorbidities of Multisymptom Illness in Australian Male Veterans of the 1991 Gulf War
Physical, Psychological, and Functional Comorbidities of Multisymptom Illness in Australian Male Veterans of the 1991 Gulf War
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DOI：
10.1093/aje/kwp238
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发表时间：
2009-10-15
影响因子：
5
通讯作者：
Dwyer, Terence
中科院分区：
文献类型：
--
作者：
Kelsall, Helen L.;McKenzie, Dean P.;Dwyer, Terence
多症状疾病在1991年海湾战争退伍军人中比军事对照组更为普遍；对合并症的了解较少。作者在2000-2002年通过问卷调查和医学评估，比较了澳大利亚第一次海湾战争男性退伍军人与积极（非海湾）部署和非部署军事人员的身体、心理和功能合并症。多症状疾病在男性海湾战争退伍军人中比对照组更常见(优势比（OR) = 1.80, 95%可信区间（CI）： 1.48, 2.19）。在对照组中按部署状态分层对这种关联没有什么影响。患有多症状疾病的海湾战争退伍军人精神疾病增加，包括重度抑郁症（OR = 6.31, 95% CI: 4.19, 9.52）和创伤后应激障碍（OR = 9.77, 95% CI: 5.39, 18.59）；不明原因慢性疲劳增加（OR = 13.32, 95% CI: 7.70, 23.05）；更多的报告功能障碍和更差的生活质量，但客观的物理和实验室结果与没有多症状疾病的退伍军人相似。在对照组中也发现了类似的模式；仅在住院治疗、阻塞性肝病和eb病毒暴露方面，三组间的差异有统计学意义。多症状疾病在第一次海湾战争退伍军人中更为普遍，但合并症的模式在积极部署和非部署的军事人员中是相似的。
Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military personnel by using a questionnaire and medical assessment in 2000-2002. Multisymptom illness was more common in male Gulf War veterans than in the comparison group (odds ratio (OR) = 1.80, 95% confidence interval (CI): 1.48, 2.19). Stratifying by deployment status in the comparison group made little difference in this association. Gulf War veterans with multisymptom illness had increased psychiatric disorders, including major depression (OR = 6.31, 95% CI: 4.19, 9.52) and posttraumatic stress disorder (OR = 9.77, 95% CI: 5.39, 18.59); increased unexplained chronic fatigue (OR = 13.32, 95% CI: 7.70, 23.05); and more reported functional impairment and poorer quality of life, but objective physical and laboratory outcomes were similar to those for veterans without multisymptom illness. Similar patterns were found in the comparison groups; differences across the 3 groups were statistically significant for only hospitalization, obstructive liver disease, and Epstein-Barr virus exposure. Multisymptom illness is more prevalent in Gulf War I veterans, but the pattern of comorbidities is similar for actively deployed and nondeployed military personnel.