Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1
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DOI：
10.1126/science.283.5407.1535
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发表时间：
1999-03-05
期刊：
影响因子：
56.9
通讯作者：
Sundstrom, P
中科院分区：
文献类型：
--
作者：
Staab, JF;Bradway, SD;Sundstrom, P
念珠菌病的发病机制涉及机会性白念珠菌的丝状形式侵入宿主组织。形态学特异性基因产物可赋予前侵袭性。一个菌丝特异性表面蛋白，Hwp1，与哺乳动物的小脯氨酸丰富的蛋白质的相似性，作为哺乳动物转氨酶的底物。缺乏Hwp1的白色念珠菌菌株不能与人颊上皮细胞形成稳定的附着，并且在小鼠中引起系统性念珠菌病的能力降低。这代表了微生物粘附的范例，涉及必需的宿主酶。
The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.