Acoustic-resolution photoacoustic microscopy based on an optically transparent focused transducer with a high numerical aperture
Acoustic-resolution photoacoustic microscopy based on an optically transparent focused transducer with a high numerical aperture
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DOI：
10.1364/ol.423287
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发表时间：
2021-07-01
期刊：
影响因子：
3.6
通讯作者：
Zou, Jun
中科院分区：
文献类型：
--
作者：
Fang, Cheng;Zou, Jun
本文报道了一种基于新型光学透明聚焦聚偏氟乙烯（PVDF）换能器的声分辨率光声显微镜（AR-PAM），其声数值孔径（NA）为0.64。由于改进了制造工艺，新型换能器的NA（0.64）远高于之前报道的低NA换能器（NA = 0.23）。声中心频率和（脉冲回波）带宽也分别增加到36和44 MHz，从而提供38 μ m的声焦斑尺寸和210 μ m的声焦深度。为了证明这一点，我们在水和鸡胸组织中的扭曲钢丝靶上进行了AR-PAM，并在老鼠尾巴上进行了活体实验。成像结果表明，通过简单紧凑的设置，可以获得较高的声分辨率和灵敏度，以分辨不同深度的目标。这种能力对于开发用于手持式、可穿戴式甚至内窥镜成像应用的新型AR-PAM系统非常有用。(C) 2021美国光学学会
This Letter reports acoustic-resolution-photoacoustic microscopy (AR-PAM) based on a new optically transparent focused polyvinylidene fluoride (PVDF) transducer with a high acoustic numerical aperture (NA) of 0.64. Owing to the improved fabrication process, the new transducer has a much higher NA (0.64) than the previously reported low-NA transducer (NA = 0.23). The acoustic center frequency and (pulse-echo) bandwidth are also increased to 36 and 44 MHz, respectively, which provides a 38 mu m acoustic focal spot size and 210 pm acoustic depth of focus. For demonstration, AR-PAM was conducted on a twisted wire target in water and chicken breast tissue, and in vivo on a mouse tail. The imaging results show that high acoustic resolution and sensitivity can be achieved with a simple and compact setup to resolve the target at different depths. Such capabilities can be useful for the development of new AR-PAM systems for handheld, wearable, and even endoscopic imaging applications. (C) 2021 Optical Society of America