miRNAs and NAFLD: from pathophysiology to therapy
miRNAs and NAFLD: from pathophysiology to therapy
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DOI：
10.1136/gutjnl-2018-318146
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发表时间：
2019-11-01
期刊：
影响因子：
24.5
通讯作者：
Foti, Michelangelo
中科院分区：
文献类型：
--
作者：
Gjorgjieva, Monika;Sobolewski, Cyril;Foti, Michelangelo
非酒精性脂肪性肝病（NAFLD）与肝脏代谢的彻底重新编程有关。表观遗传机制，特别是与microRNA（miRNAs）的表达和活性的失调相关的那些，在与NAFLD相关的代谢紊乱及其向疾病的更严重阶段的进展中起主要作用。在这篇综述中，我们讨论了复杂的miRNA调控网络的许多方面在NAFLD的发展和进展中的作用的最新进展。讨论了miRNA介导的基因调控的基本概念和机制，以及在这一领域的基础和转化研究中遇到的各种挫折。目前发现的miRNAs在NAFLD中的表达/活性失调，并有助于这种病理学的结果进一步审查。最后，在短期到中期的潜在治疗用途的基于miRNA的策略在NAFLD，特别是确定非侵入性生物标志物，或设计药理学类似物/抑制剂具有广泛的行动对肝脏代谢，突出。
Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of hepatic metabolism. Epigenetic mechanisms, in particular those associated with deregulation of the expressions and activities of microRNAs (miRNAs), play a major role in metabolic disorders associated with NAFLD and their progression towards more severe stages of the disease. In this review, we discuss the recent progress addressing the role of the many facets of complex miRNA regulatory networks in the development and progression of NAFLD. The basic concepts and mechanisms of miRNA-mediated gene regulation as well as the various setbacks encountered in basic and translational research in this field are debated. miRNAs identified so far, whose expressions/activities are deregulated in NAFLD, and which contribute to the outcomes of this pathology are further reviewed. Finally, the potential therapeutic usages in a short to medium term of miRNA-based strategies in NAFLD, in particular to identify non-invasive biomarkers, or to design pharmacological analogues/inhibitors having a broad range of actions on hepatic metabolism, are highlighted.