En route to an efficient catalytic asymmetric synthesis of AS-3201
En route to an efficient catalytic asymmetric synthesis of AS-3201
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DOI：
10.1021/ja0752585
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发表时间：
2007-09-19
影响因子：
15
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Mashiko, Tomoyuki;Hara, Keiichi;Shibasaki, Masakatsu
描述了通过新型镧-酰胺络合物的催化不对称胺化催化不对称合成 AS-3201。胺化反应在催化剂负载量低至 1 mol% 的情况下即可高效进行，从而能够有效获得合成强效醛糖还原酶抑制剂 AS-3201 的关键中间体。
A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.