Reference ranges for serial measurements of blood velocity and pulsatility index at the intra-abdominal portion, and fetal and placental ends of the umbilical artery
Reference ranges for serial measurements of blood velocity and pulsatility index at the intra-abdominal portion, and fetal and placental ends of the umbilical artery
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DOI：
10.1002/uog.1902
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发表时间：
2005-08-01
影响因子：
7.1
通讯作者：
Kiserud, T
中科院分区：
文献类型：
--
作者：
Acharya, G;Wilsgaard, T;Kiserud, T
目的建立正常妊娠后半期超声辐照脐动脉（UA）血流速度和搏动指数（PI）的参考范围。对130例低危单胎孕妇于孕19-42周每隔4周分别于腹腔内、胎末及胎盘末测定UA血流速度。结果UA血流速度和PI值在腹腔内和胎儿端均高于胎盘端。与胎龄相关的舒张末期血流速度的增加大于相应的收缩期峰值血流速度的增加。随着孕周的增加，胎儿与胎盘脐动脉血流速度差值（Δ值）逐渐增大，PI值逐渐减小。我们已经建立了新的参考范围的UA速度和PI在标准化的位置的基础上纵向观察，这应该是有用的胎儿的监测与重复观察。Copyright（c）2005 ISUOG.出版社：John Wiley & Sons，Ltd
Objective To construct reference ranges for serial measurements of umbilical artery (UA) blood flow velocity and pulsatility index (PI) at standardized insonation sites during the second half of pregnancy.Methods This was a prospective longitudinal study of the umbilical circulation. UA blood flow velocities were measured at the intra-abdominal portion, fetal end and placental end at 4-weekly intervals at 19-42 weeks of gestation in 130 low-risk singleton pregnancies. A total of 513 observations were used to construct the reference ranges using regression statistics and multilevel modeling.Results UA blood velocities and PI were higher at the intra-abdominal portion and fetal end than at the placental end. The gestational age-related increase of end-diastolic velocity was greater than the corresponding increase of the peak systolic velocity at all locations. The mean differences (delta values) of UA blood velocities between the fetal and placental ends increased and that of PI decreased with advancing gestational age.Conclusion UA Doppler parameters vary significantly at different locations. We have established new reference ranges for the UA velocities and PI at standardized locations based on longitudinal observations, which should be useful for the surveillance of fetuses with repeated observations. Copyright (c) 2005 ISUOG. Published by John Wiley & Sons, Ltd.