Method for establishing and measuring in vivo forces in an anterior cruciate ligament composite graft: response to differing levels of load sharing in a goat model.
Method for establishing and measuring in vivo forces in an anterior cruciate ligament composite graft: response to differing levels of load sharing in a goat model.
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建立和测量前十字韧带复合移植物体内力的方法：对山羊模型中不同水平的负载分配的响应。
DOI：
10.1002/jor.1100120605
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Lew,WD
中科院分区：
文献类型：
--
作者：
Lewis,JL;Poff,BC;Smith,JJ;Lindquist,C;Engebretsen,L;Lew,WD
为了确定前交叉韧带移植物最佳重建的适当载荷历史，需要建立和测量体内移植物力的方法。我们本研究的目的是（a）开发一种方法，在该方法中，可以将由外部载荷引起的移植物力设置为活体动物的预选值，（B）表明该力可以在固定后保持不变，以及（c）确定在动物术后长达2周的功能恢复后，力会发生什么变化。当在外科手术中设置节段之间的不同水平的负荷分担时。在12只山羊中使用骨-髌腱-骨移植物和合成增强器械重建前交叉韧带。在手术固定时，使用力设定技术确定移植物节段中的力。在5只动物中，肌腱节段被设定为承受总移植物力的90%;在其余7只动物中，加固节段被设定为分担总移植物力的90%。固定前后和术后2周，在膝关节屈曲60°的情况下，在67 N的胫骨前载荷下，使用安装在胫骨前关节外的带扣传感器测量移植物力。当肌腱是高承载力构件时，肌腱中的力在手术固定后2周内平均下降25%，而加固节段中的力显著增加111%。当加固节段是高承载节段时，该节段的力在2周内平均下降10%，肌腱力增加47%。这些数据表明，当肌腱被设置为承受高力时，由于组织的生物学变化，肌腱可能会拉伸，并且当其被设置为承受大部分总载荷时，加固节段在术后2周内没有受到太大影响。由于移植物节段通过胫骨前部骨轮廓周围的摩擦效应，以及手术中屈曲传感器的校准用于减少术后2周的力数据，因此本研究中测量的移植物节段力存在不确定性。然而，如果动物在试验后2周被处死，并且屈曲传感器在试验后立即校准，则这些不确定性将不存在。
In order to determine the appropriate load history for optimal remodeling of an anterior cruciate ligament graft, methods for establishing and measuring graft forcesin vivoare required. Our objectives with this study were to (a) develop a method in which the graft force due to an external load could be set to a preselected value in a living animal, (b) show that this force could be maintained after fixation, and (c) determine what happens to the forces after the animal has functioned for as long as 2 weeks postoperatively, when differing levels of load sharing between the segments had been set at surgery. The anterior cruciate ligament was reconstructed in 12 goats with use of a bone‐patellar tendon‐bone graft and a synthetic augmentation device. The forces in the graft segments were established, at the time of surgical fixation, with use of a force‐setting technique. In five animals, the tendon segment was set to carry 90% of the total graft force; in the remaining seven animals, the augmentation segment was set to share 90% of the total graft force. Graft forces were measured, with the use of buckle transducers mounted extra‐articularly over the anterior tibia, under a 67 N anterior tibial load at 60° of knee flexion before and after fixation and at 2 weeks postoperatively. When the tendon was the high force‐carrying member, the force in the tendon decreased by an average of 25% during the 2 weeks after surgical fixation, while the force in the augmentation segment showed a significant increase of 111%. When the augmentation segment was the high force‐carrying segment, the force in that segment decreased by an average of 10% during the 2 weeks and the tendon force increased by 47%. These data suggest that when the tendon was set to carry high force, it may have stretched, due to biological changes in the tissue, and that the augmentation segment was not as greatly affected over the 2 postoperative weeks when it was set to carry most of the total load. Because of the frictional effects of the graft segments passing around the osseous contours of the anterior tibia and the fact that the calibrations of the buckle transducer from surgery were used to reduce the data on force at 2 weeks postoperatively, there are uncertainties related to the measured graft segment forces in this study. However, if the animals had been killed and the buckle transducers calibrated immediately after the test at 2 weeks, these uncertainties would not exist.