A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies
A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies
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DOI：
10.4161/cib.7708
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发表时间：
2009-03
影响因子：
--
通讯作者：
T. Sokabe;M. Tominaga
中科院分区：
文献类型：
--
作者：
T. Sokabe;M. Tominaga
动物必须能够感知危险的温度，以避免身体伤害。最近的进展揭示了这种能力背后的分子机制。这一基本功能需要哺乳动物和果蝇中瞬时受体电位（TRP）通道家族的一个子集。我们最近发现，果蝇TRP通道，被称为无痛，具有热敏感性，这是必要的避免有毒热。Painless激活的温度阈值与体内引起回避行为的温度一致，表明Painless在果蝇中充当主要的有害热探测器。本文综述了果蝇温度敏感性TRP通道（包括Painless）的特性。
Animals must be capable of sensing hazardous temperatures to avoid physical injury. Recent progress has revealed the molecular mechanisms underlying this capability. This essential function requires a subset of the Transient Receptor Potential (TRP) channel family in both mammals and Drosophila. We recently showed that a Drosophila TRP channel, dubbed Painless, possesses heat sensitivity that is essential for avoidance of noxious heat. The temperature threshold for Painless activation is consistent with the temperatures that cause avoidance behaviors in vivo, indicating that Painless acts as a primary noxious heat detector in Drosophila. In this review, we summarize the properties of temperature-sensitive TRP channels, including Painless, in fruit flies.