OLIGOTHYMIDYLATES SUBSTITUTED AT POSITION 5', AT BOTH POSITIONS 5' AND 3', OR ON AN INTERNUCLEOTIDIC PHOSPHATE BY AN ACRIDINE DERIVATIVE
OLIGOTHYMIDYLATES SUBSTITUTED AT POSITION 5', AT BOTH POSITIONS 5' AND 3', OR ON AN INTERNUCLEOTIDIC PHOSPHATE BY AN ACRIDINE DERIVATIVE
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DOI：
10.1080/07328318808075389
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发表时间：
1988-01-01
影响因子：
1.3
通讯作者：
THUONG, NT
中科院分区：
文献类型：
--
作者：
ASSELINE, U;THUONG, NT
用磷酸三酯法在溶液中合成了与吖啶衍生物（2-甲氧基-6-氯-9-氨基吖啶）共价连接的低胸苷酸酯。取代是在5‘’位置上进行的，在5‘’和3‘’位置上或在核间磷酸基上。用聚亚甲基连接剂通过9-氨基将吖啶衍生物连接到末端或核间磷酸。
Oligothymidylates covalently linked to an acridine derivative (2-methoxy-6-chloro-9-aminoacridine) have been synthesized by the phosphotriester method in solution. The substitution has been carried out at the 5'' position, both at the 5'' and 3'' positions or on an internucleotidic phosphate. A polymethylene linker was used to tether the acridine derivative via its 9-amino group to the terminal or internucleotidic phosphate.