Cardiac catecholamine stores after cardiac sympathectomy, 6-OHDA, and cardiac denervation.
Cardiac catecholamine stores after cardiac sympathectomy, 6-OHDA, and cardiac denervation.
复制标题
心脏交感神经切除、6-OHDA 和心脏去神经支配后心脏儿茶酚胺储存。
DOI：
10.1152/ajpheart.1981.240.6.h889
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Simpson,WW
中科院分区：
文献类型：
--
作者：
Priola,DV;O'Brien,WJ;Dail,WG;Simpson,WW
已知交感神经通过经典迷走神经通路到达心脏。因此，如果迷走神经保持完整，双侧颈胸交感神经切除术（CS）可能会在心肌中留下大量可释放的儿茶酚胺。比较了CS、外源性心脏去神经（CD）和6-羟基多巴胺（6-OHDA）化学交感神经切除术动物对酪胺（冠状动脉内500 μ g）的心脏反应。将犬置于心肺转流术中，并记录心脏的等容压。在对照动物中，酪胺引起心率（58%）和等容压（86-170%）显著增加。10只CS动物表现出与对照动物无法区分的反应。4只CD和4只6-OHDA动物对酪胺无反应。在CS动物中阿托品后刺激颈部迷走神经产生心动过速。组织荧光研究表明，在这一组中存在显着数量的心脏肾上腺素能纤维。CS动物的正常酪胺反应性归因于1）颈胸交感神经切除术后心脏中保留了大量迷走肾上腺素能纤维，以及2）去神经超敏反应，使心脏对残留的儿茶酚胺非常敏感。
Sympathetic nerves are known to reach the heart via classical vagal pathways. Bilateral cervicothoracic sympathectomy (CS) might be expected therefore to leave significant amounts of releasable catecholamines in the myocardium if the vagi are left intact. Cardiac responses to tyramine (500 micrograms intracoronary) were compared in animals with CS, extrinsic cardiac denervation (CD), and chemical sympathectomy with 6-hydroxydopamine (6-OHDA). Dogs were placed on cardiopulmonary bypass and isovolumic pressures were recorded from the heart. In control animals, tyramine caused profound increases in rate (58%) and isovolumic pressures (86-170%). Ten CS animals demonstrated responses indistinguishable from control animals. Four CD and four 6-OHDA animals showed no response to tyramine. Cervical vagal stimulation after atropine in the CS animals produced tachycardia. Histofluorescent studies demonstrated the presence of significant numbers of cardiac adrenergic fibers in this group. The normal tyramine responsiveness of the CS animals was attributed to 1) significant numbers of vagal adrenergic fibers remaining in the heart after cervicothoracic sympathectomy, and 2) denervation supersensitivity, rendering the heart very responsive to the catecholamine that remains.