Severe combined immunodeficiency signalized by eosinophilia and lymphopenia in rotavirus infected infants
Severe combined immunodeficiency signalized by eosinophilia and lymphopenia in rotavirus infected infants
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DOI：
10.1055/s-2007-985877
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发表时间：
2007-11-01
影响因子：
1
通讯作者：
Niehues, T.
中科院分区：
文献类型：
--
作者：
Hennewig, U.;Schulz, A.;Niehues, T.
背景：严重联合免疫缺陷（SCID）是一种异质性疾病，由几种不同的亚型组成。大多数亚型在婴儿期出现，如果不治疗，感染通常会导致早期死亡。SCID的诊断可能很困难，因为预计很快就会发现新的亚型。诊断晚与预后差有关。由于免疫力受损，轮状病毒肠炎等感染在SCID儿童中无法清除。本研究的目的是确定轮状病毒肠炎患儿的线索，帮助早期诊断SCID.Patients和Methods：将诊断时持续轮状病毒感染的SCID患者队列（n=18）的总白色血细胞计数与无SCID但有轮状病毒感染的匹配对照患者的总白色血细胞计数进行比较。结论：轮状病毒感染患儿应进行全血细胞计数，嗜酸性粒细胞增多和/或淋巴细胞减少应高度怀疑SCID。
Background: Severe combined immunodeficiency (SCID) is a heterogeneous disease consisting of several different subtypes. Most subtypes present during infancy and without treatment, infections usually lead to early death. Diagnosis of SCID can be difficult as new subtypes are expected to be discovered soon. Late diagnosis is associated with a poorer outcome. Infections like rotavirus enteritis cannot be cleared in children with SCID due to impaired immunity. The aim of our study was to identify clues in children with rotavirus enteritis that aid to diagnose SCID early.Patients and Methods: Total white blood counts in a cohort of SCID patients with persistent rotavirus infection at diagnosis (n=18) were compared to total white blood counts in matched control patients without SCID but with rotavirus infection.Results: Relative and absolute lymphopenia and eosinophilia were more common in SCID patients (p < 0.005).Conclusion: In infants with rotavirus infection, a full blood count should be performed: Eosinophilia and/or lymphopenia raise a high suspicion of SCID.