Spatial representations of self and other in the hippocampus
Spatial representations of self and other in the hippocampus
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DOI：
10.1126/science.aao3898
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发表时间：
2018-01-12
期刊：
影响因子：
56.9
通讯作者：
Fujisawa, Shigeyoshi
中科院分区：
文献类型：
--
作者：
Danjo, Teruko;Toyoizumi, Taro;Fujisawa, Shigeyoshi
动物对其空间位置的感知取决于海马体中位置细胞的活动。大脑是如何对他人的空间位置进行编码的，目前还不清楚。我们通过观察t迷宫任务研究了其他动物在海马背侧CA1区位置的神经元表征，在该任务中，一只大鼠被要求观察另一只大鼠的轨迹以成功获取奖励。观察大鼠的CA1锥体细胞对反映自我和他者空间位置的信息进行联合和离散编码。CA1锥体细胞的一个子集表现出对自我和他人相同的空间接受野。这些发现表明，海马体的空间表征包括自我和非我两个维度。
An animal's awareness of its location in space depends on the activity of place cells in the hippocampus. How the brain encodes the spatial position of others has not yet been identified. We investigated neuronal representations of other animals' locations in the dorsal CA1 region of the hippocampus with an observational T-maze task in which one rat was required to observe another rat's trajectory to successfully retrieve a reward. Information reflecting the spatial location of both the self and the other was jointly and discretely encoded by CA1 pyramidal cells in the observer rat. A subset of CA1 pyramidal cells exhibited spatial receptive fields that were identical for the self and the other. These findings demonstrate that hippocampal spatial representations include dimensions for both self and nonself.