Complex networks approach for analyzing the correlation of traditional chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease.
Complex networks approach for analyzing the correlation of traditional chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease.
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复杂网络方法分析稳定性冠心病患者中医证候演变与心血管事件的相关性
DOI：
10.1155/2015/824850
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Gao Z;Li S;Shang Q;Jiao Y;Zhou X;Fu C;Xu H;Shi D;Chen K
这是一项多中心前瞻性队列研究，旨在分析稳定性冠心病(CHD)患者中医证候演变与心血管事件的相关性。采用复杂网络方法分析6个月和12个月随访期间证候演变对心血管事件的影响。卡方检验结果显示，心血管事件的发生与证候演变呈正相关，从中毒证演变为气虚血瘀证或持续中毒证，从气虚演变为血瘀证或持续气虚证，从血瘀证演变为气虚证。血瘀证、气虚证、中毒证是冠心病稳定期的重要证候因素。心脑血管事件与证候由中毒证向气虚或血瘀证演变、由气虚向血瘀证演变、或由中毒证向气虚演变呈正相关。提示冠心病稳定期患者具有毒消耗气机、毒导致血瘀证、气虚血瘀证相互转化的病机，易发生再发心血管事件。
This is a multicenter prospective cohort study to analyze the correlation of traditional Chinese medicine (TCM) syndrome evolvement and cardiovascular events in patients with stable coronary heart disease (CHD). The impact of syndrome evolvement on cardiovascular events during the 6-month and 12-month follow-up was analyzed using complex networks approach. Results of verification using Chi-square test showed that the occurrence of cardiovascular events was positively correlated with syndrome evolvement when it evolved from toxic syndrome to Qi deficiency, blood stasis, or sustained toxic syndrome, when it evolved from Qi deficiency to blood stasis, toxic syndrome, or sustained Qi deficiency, and when it evolved from blood stasis to Qi deficiency. Blood stasis, Qi deficiency, and toxic syndrome are important syndrome factors for stable CHD. There are positive correlations between cardiovascular events and syndrome evolution from toxic syndrome to Qi deficiency or blood stasis, from Qi deficiency to blood stasis, or toxic syndrome and from blood stasis to Qi deficiency. These results indicate that stable CHD patients with pathogenesis of toxin consuming Qi, toxin leading to blood stasis, and mutual transformation of Qi deficiency and blood stasis are prone to recurrent cardiovascular events.