Neurocognitive performance and functional disability in the psychosis prodrome
Neurocognitive performance and functional disability in the psychosis prodrome
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DOI：
10.1016/j.schres.2006.02.005
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发表时间：
2006-05-01
影响因子：
4.5
通讯作者：
Cannon, Tyrone D.
中科院分区：
文献类型：
--
作者：
Niendam, Tara A.;Bearden, Carrie E.;Cannon, Tyrone D.
目的：本研究评估的模式，神经心理缺陷和他们的关联与临床病理学和社会功能的个人确定为超高风险（UHR）为psychiatris.Methods：一个样本的45个UHR的个人被确定为使用结构化面试前驱综合征（SIPS）从连续转介到斯塔格林音乐节中心的评估和预防前驱状态（CAPPS）在加州大学洛杉矶分校。参与者进行了神经认知测试电池，以及全球（施特劳斯-卡彭特成果量表）和社会功能（加州大学洛杉矶分校社会成就调查）的措施。结果：参与者表现出显着的缺陷，在处理速度，语言学习和记忆，和运动速度。后言语学习和记忆表现与较差的社会功能显着相关，推理和解决问题的表现较差的趋势与较差的全球功能。言语记忆独立预测的社会功能和以上的严重程度的阴性症状。认知功能障碍与临床症状的严重程度无关。结论：尽管没有完全的精神病症状，UHR个体经历显着的认知功能障碍，特别是在任务上，需要加快信息处理和有效的回忆从记忆，这些赤字似乎与功能障碍的方式平行，观察到在患者建立精神病。(c)2006 Elsevier B.V.保留所有权利。
Objective: This study evaluates the pattern of neuropsychological deficits and their association with clinical symptomatology and social functioning in individuals identified as ultra-high-risk (UHR) for psychosis.Methods: A sample of 45 UHR individuals was identified using the Structured Interview for Prodromal Syndromes (SIPS) from consecutive referrals to the Staglin Music Festival Center for the Assessment and Prevention of Prodromal States (CAPPS) at UCLA. Participants were administered a neurocognitive test battery, as well as measures of global (Strauss-Carpenter Outcome Scale) and social functioning (UCLA Social Attainment Survey).Results: Participants showed significant deficits in speed of processing, verbal learning and memory, and motor speed. Poorer verbal learning and memory performance was significantly associated with poorer social functioning, and there was a trend for poorer performance on reasoning and problem solving to be associated with poorer global functioning. Verbal memory independently predicted social functioning over and above severity of negative symptoms. Cognitive deficits were not associated with severity of clinical symptomatology.Conclusions: Despite the absence of fully psychotic symptoms, UHR individuals experience significant cognitive deficits, particularly on tasks requiring speeded information-processing and efficient recall from memory, and these deficits appear to be associated with functional disability in a manner parallel to that observed in patients with established psychotic illness. (c) 2006 Elsevier B.V. All rights reserved.